Flip the coin: IL-7 and IL-7R in health and disease

被引：229
|
作者：
Barata, Joao T. [1 ]
Durum, Scott K. [2 ]
Seddon, Benedict [3 ]
机构：
[1] Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal
[2] NCI, Canc & Inflammat Program, Frederick, MD 21701 USA
[3] UCL, Inst Immun & Transplantat, Div Infect & Immun, London, England
来源：
NATURE IMMUNOLOGY | 2019年 / 20卷 / 12期
基金：
美国国家卫生研究院; 欧洲研究理事会; 巴西圣保罗研究基金会;
关键词：
ACUTE LYMPHOBLASTIC-LEUKEMIA; OF-FUNCTION MUTATIONS; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; JAK/STAT PATHWAY INHIBITION; CD8; T-CELLS; RECEPTOR-ALPHA; INTERLEUKIN-7; IL-7; HIGH-RISK; IN-VIVO; IL-7-MEDIATED VIABILITY;
D O I：
10.1038/s41590-019-0479-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive Tcells, and generation and maintenance of memory Tcells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures and barrier defense. Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their 'dark side' as promoters of cancer development. We also explore therapeutic implications and opportunities associated with either positive or negative modulation of the IL-7-IL-7R signaling axis.
引用
收藏
页码：1584 / 1593
页数：10
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