Pathogenicity of mumps virus in the marmoset

被引:12
|
作者
Saika, S [1 ]
Kidokoro, M [1 ]
Ohkawa, T [1 ]
Aoki, A [1 ]
Suzuki, K [1 ]
机构
[1] Chiba Serum Inst, Chiba, Japan
关键词
mumps virus; animal model; neurovirulence; marmoset;
D O I
10.1002/jmv.2119
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The neurovirulence of two mumps virus strains was compared using marmosets. Marmosets were inoculated intravenously with the wild-type mumps virus Odate strain, resulting in evident meningitis in 1 of 3 marmosets at each of the weeks 3, 4, and 5 postinoculation, representing a total of 3 out of 9 marmosets. Nephritis, parotitis, pancreatitis, and tonsillitis were manifest in addition to central nervous system (CNS) sequelae. On the other hand, the Jeryl Lynn vaccine strain did not induce histopathological changes in the CNS and multiplication of the Jeryl Lynn strain was distinctly lower compared to that of the Odate strain in the marmoset. This is the first report to describe the induction of meningitis in non-human primates after peripheral inoculation of a wild-type mumps virus, presenting findings useful for the elucidation of the mechanism of infection and pathology of mumps virus in the CNS. The distinction observed between the Odate and Jeryl Lynn strains suggests the applicability of the marmoset model for the evaluation of any neurovirulence potential of vaccine strains. (C) 2002 Wiley-Liss, Inc.
引用
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页码:115 / 122
页数:8
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