Expression and Content of Protein LC3B in Gastric Cancer Tissue, Relationship with Expression of mTOR, AMPK in Gastric Cancer Tissue and HER2 and PD-L1 Status of the Tumor

被引：2

作者：

Spirina, L., V ^{[1
]}

Avgustinovich, A., V ^{[1
]}

Afanas'ev, S. G. ^{[1
]}

Volkov, M. Yu ^{[1
]}

Kondakova, I., V ^{[1
]}

机构：

[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Canc Res Inst, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 172卷 / 02期

关键词：

gastric cancer; LC3B; HER2 tumor status; PD-L1 tumor status;

D O I：

10.1007/s10517-021-05376-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Analysis of HER2 status of the tumor and expression of mTOR, AMPK showed a decrease in mTOR mRNA level in HER2(+) tumors in comparison with HER- status. The appearance of PD-L1(+) transformed cells in the tumor was associated with increased expression of the LC3B gene and elevated content of the corresponding protein measured after treatment.

引用

页码：202 / 205

页数：4

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