Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment?

被引：6
|
作者：
Madariaga, Ainhoa [1 ]
Goodwin, Pamela J. [2 ,3 ]
Oza, Amit M. [1 ,4 ]
机构：
[1] Princess Margaret Canc Ctr, Bras Family Drug Dev Program, Div Med Oncol & Hematol, Toronto, ON, Canada
[2] Mt Sinai Hosp, Div Med Oncol, Toronto, ON, Canada
[3] Univ Toronto, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada
[4] Univ Toronto, Toronto, ON, Canada
来源：
CLINICAL CANCER RESEARCH | 2020年 / 26卷 / 03期
关键词：
PHASE-II; RECURRENT; TRIAL;
D O I：
10.1158/1078-0432.CCR-19-3645
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metformin is an affordable and well-tolerated drug used in type 2 diabetes. Potential anticancer effects of metformin in gynecologic malignancies include inhibition of the PI3K-mTOR pathway, hormone receptor regulation, and reduction of fibrosis and inflammation. Multiple studies are currently assessing its role in cancer prevention and as a treatment enhancer.
引用
收藏
页码：523 / 525
页数：3
相关论文
共 50 条
  • [21] Management of lymph nodes in the treatment of gynecologic cancers
    Kamura, Toshiharu
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2007, 12 (03) : 163 - 164
  • [22] Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease
    Tang, Yali
    Zhang, Yizhu
    Chen, Chen
    Cao, Ying
    Wang, Qiaona
    Tang, Chuanfeng
    JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE, 2025, 17
  • [23] Opening a New Time Window for Treatment of Stroke by Targeting HDAC2
    Lin, Yu-Hui
    Dong, Jian
    Tang, Ying
    Ni, Huan-Yu
    Zhang, Yu
    Su, Ping
    Liang, Hai-Ying
    Yao, Meng-Cheng
    Yuan, Hong-Jin
    Wang, Dong-Liang
    Chang, Lei
    Wu, Hai-Yin
    Luo, Chun-Xia
    Zhu, Dong-Ya
    JOURNAL OF NEUROSCIENCE, 2017, 37 (28): : 6712 - 6728
  • [24] Cyclotherapy: opening a therapeutic window in cancer treatment
    van Leeuwen, Ingeborg M. M.
    ONCOTARGET, 2012, 3 (06) : 596 - 600
  • [25] Repositioning metformin for cancer prevention and treatment
    Quinn, Brendan J.
    Kitagawa, Hiroshi
    Memmott, Regan M.
    Gills, Joell J.
    Dennis, Phillip A.
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2013, 24 (09): : 469 - 480
  • [26] Repurposing of Metformin for the prevention and treatment of Tuberculosis
    Vyas, Navya
    Punchathidil, Rakhi
    Swain, Ansuman
    Shakeer, Irfan
    Reddy, Badikol Shrikar
    Manu, Mohan Kamalanivas
    Miraj, Sonal Sekhar
    BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 58
  • [27] EFFECT OF HERBAL MEDICINE DAIKENCHUTO FOR THE PREVENTION OF POSTOPERATIVE ILEUS IN GYNECOLOGIC CANCERS
    Oshima-Sudo, N.
    Furusawa, A.
    Wakana, K.
    Wakabayashi, A.
    Terauchi, M.
    Obayashi, S.
    Kubota, T.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2014, 24 (09) : 1263 - 1263
  • [28] The Role of Immunotherapy in the Treatment of Gynecologic Cancers: A Systematic Review
    Farajimakin, Olugbenga
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (07)
  • [29] Exploiting synthetic lethality in the treatment of gynecologic cancers.
    Lord, Christopher J.
    CLINICAL CANCER RESEARCH, 2018, 24 (15) : 21 - 21
  • [30] Imaging the post-treatment pelvis with gynecologic cancers
    Moradi, Behnaz
    Hejazian, Seyyed Sina
    Tahamtan, Mohammadreza
    Ghorani, Hamed
    Karami, Shaghayegh
    ABDOMINAL RADIOLOGY, 2024, 49 (04) : 1248 - 1263
12345