Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment?

被引：6
|
作者：
Madariaga, Ainhoa [1 ]
Goodwin, Pamela J. [2 ,3 ]
Oza, Amit M. [1 ,4 ]
机构：
[1] Princess Margaret Canc Ctr, Bras Family Drug Dev Program, Div Med Oncol & Hematol, Toronto, ON, Canada
[2] Mt Sinai Hosp, Div Med Oncol, Toronto, ON, Canada
[3] Univ Toronto, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada
[4] Univ Toronto, Toronto, ON, Canada
来源：
CLINICAL CANCER RESEARCH | 2020年 / 26卷 / 03期
关键词：
PHASE-II; RECURRENT; TRIAL;
D O I：
10.1158/1078-0432.CCR-19-3645
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metformin is an affordable and well-tolerated drug used in type 2 diabetes. Potential anticancer effects of metformin in gynecologic malignancies include inhibition of the PI3K-mTOR pathway, hormone receptor regulation, and reduction of fibrosis and inflammation. Multiple studies are currently assessing its role in cancer prevention and as a treatment enhancer.
引用
收藏
页码：523 / 525
页数：3
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