Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

被引:72
|
作者
Rafiq, Shamaila [1 ]
Jeppesen, Per Bendix [1 ]
机构
[1] Aarhus Univ, Dept Clin Med, DK-8200 Aarhus, Denmark
关键词
hypovitaminosis D; type; 2; diabetes; body mass index; Vitamin D; BMI; SERUM 25-HYDROXYVITAMIN D; CARDIOMETABOLIC RISK-FACTORS; BONE-MINERAL DENSITY; METABOLIC SYNDROME; INSULIN-RESISTANCE; D DEFICIENCY; D LEVEL; HYPOVITAMINOSIS-D; POSTMENOPAUSAL WOMEN; D INSUFFICIENCY;
D O I
10.3390/nu10091182
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The deficiency of vitamin D is prevalent all over the world. Studies have shown that vitamin D may play an important role in the development of obesity. The current study was conducted to quantitatively evaluate the association between serum 25-(OH) vitamin D levels and the risk of obesity in both diabetic and non-diabetic subjects. A systematic review and meta-analysis of observational studies was carried out for that purpose. We searched the Medline, PubMed, and Embase databases throughout all of March 2018. A total of fifty five observational studies for both diabetic and non-diabetic subjects were finally included in the meta-analysis. The data were analyzed by comprehensive meta-analysis software version 3 and the random effects model was used to analyze the data. The meta-analysis showed an overall inverse relationship between serum vitamin D status and body mass index (BMI) in studies of both diabetic (r = -0.173, 95% = -0.241 to -0.103, p = 0.000) and non-diabetic (r = -0.152, 95% = -0.187 to -0.116, p = 0.000) subjects. The evidence of publication bias was not found in this meta-analysis. In conclusion, the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects. Reliable evidence from well-designed future randomized controlled trials is required to confirm the findings from observational studies and to find out the potential regulatory effects of vitamin D supplementation to lower BMI.
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页数:20
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