Sesquiterpenoids isolated from an endophyte fungus Diaporthe sp.

被引:23
|
作者
Chen, Chao-Jun [1 ]
Liu, Xian-Xian [1 ]
Zhang, Wen-Jing [1 ]
Zang, Le-Yun [1 ]
Wang, Gang [1 ]
Ng, Seik Weng [2 ]
Tan, Ren-Xiang [1 ]
Ge, Hui-Ming [1 ]
机构
[1] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
[2] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia
关键词
D O I
10.1039/c4ra13136c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ten new sesquiterpenoids including six brasilane-type sesquiterpenoids, diaporols J-O (1-6), a 3,6-cycloprecapnellane sesquiterpenoid, diaporol P (7), and three drimane sesquiterpenoids, diaporols Q-S (8-10) were isolated from Diaporthe sp., an endophytic fungus associated with the leaves of Rhizophora stylosa collected in Hainan Province, China. The structures of these compounds were elucidated by extensive analysis of NMR, MS, CD spectra and single crystal X-ray diffraction. Among them, compound 9 exhibited moderate cytotoxicity against the SW480 cell line with an IC50 value of 8.72 +/- 1.32 mu M.
引用
收藏
页码:17559 / 17565
页数:7
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