Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria

被引：19
|
作者：
Wang, Shumin [1 ,2 ]
Sugahara, Kazuyuki [3 ,4 ]
Li, Fuchuan [1 ,2 ]
机构：
[1] Shandong Univ, Natl Glycoengn Res Ctr, Shandong Prov Key Lab Carbohydrate Chem & Glycobi, Jinan 250100, Peoples R China
[2] Shandong Univ, Shenzhen Res Inst, Jinan 250100, Peoples R China
[3] Hokkaido Univ, Grad Sch Life Sci, Fac Adv Life Sci, Proteoglycan Signaling & Therapeut Res Grp, Sapporo, Hokkaido 0010021, Japan
[4] Fac Pharm, Dept Pathobiochem, Nagoya, Aichi 4688503, Japan
来源：
GLYCOCONJUGATE JOURNAL | 2016年 / 33卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Glycosaminoglycan; Chondroitin sulfate; Dermatan sulfate; Sulfatase; HUMAN N-ACETYLGALACTOSAMINE-6-SULFATE SULFATASE; HUMAN GUT SYMBIONT; ARYLSULFATASE-B; DERMATAN SULFATE; FLAVOBACTERIUM-HEPARINUM; BACTEROIDES-THETAIOTAOMICRON; POSTTRANSLATIONAL FORMATION; STREPTOCOCCUS-INTERMEDIUS; SEQUENTIAL DEGRADATION; MARINE BACTERIUM;
D O I：
10.1007/s10719-016-9720-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sulfatases that specifically catalyze the hydrolysis of the sulfate groups on chondroitin sulfate (CS)/dermatan sulfate (DS) poly- and oligosaccharides belong to the formylglycine-dependent family of sulfatases and have been widely found in various mammalian and bacterial organisms. However, only a few types of CS/DS sulfatase have been identified so far. Recently, several novel CS/DS sulfatases have been cloned and characterized. Advanced studies have provided significant insight into the biological function and mechanism of action of CS/DS sulfatases. Moreover, further studies will provide powerful tools for structural and functional studies of CS/DS as well as related applications. This article reviews the recent progress in CS/DS sulfatase research and is expected to initiate further research in this field.
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页码：841 / 851
页数：11
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