Comparative study of lumboperitoneal shunt and ventriculoperitoneal shunt in the treatment of idiopathic normal pressure hydrocephalus

Objective: This study aimed to compare lumboperitoneal shunt (LPS) and ventriculoperitoneal shunt (VPS) in the treatment of idiopathic normal pressure hydrocephalus (iNPH). Methods: From September 2016 to November 2019, 76 iNPH patients who underwent shunt operation were recruited and assigned to a lumboperitoneal shunt group (LPS group, n=40) and a ventriculoperitoneal shunt (VPS group, n=36) according to different treatment methods. The right first time (RFT) and improvement in triad of the two groups were observed. Keifer's hydrocephalus score (KHS) was used to evaluate the improvement of clinical symptoms, Mini-Mental State Examination (MMSE) and National Institutes of Health Stroke Scale (NIHSS) were used to evaluate the improvement of cognitive func-tion, and the Functional Independence Measure (FIM) to evaluate the postoperative living status of patients. The two groups of patients were followed up for 6 months to observe the postoperative curative effect and incidence of complications. Results: The RFT of LPS group was markedly higher than that of VPS group. There was no remarkable difference in the improvement of triad, KHS score, MMSE score, NIHSS score, and FIM score between the two groups after treatment, as well as overall response rate (ORR) after six months. The total incidence of complications in LPS group was considerably lower than that in VPS group. Conclusion: LPS and VPS have similar curative effect in the treatment of iNPH, but LPS can avoid intraparenchymal hemorrhage (IPH) caused by ventricular puncture, and it increases the RFT.