Differential pulse voltammetric determination of uric acid on carbon-coated iron nanoparticle modified glassy carbon electrodes

A carbon-coated iron nanoparticles (CIN, a new style fullerence related nanomaterial) modified glassy carbon electrode (CIN/GCE) has been developed for the determination of uric acid (UA). Electrochemical behaviors of UA on CIN/GCE were explored by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). It was found that the voltammetric response of UA on CIN/GC was enhanced dramatically because of the strong accumulation effect of CIN and the large working area of the CIN/GC electrode. The parameters including the pH of supporting electrolyte, accumulation potential and time, that govern the analytical performance of UA have been studied and optimized. The DPV signal of UA on CIN/GCE increased linearly with its concentration in the range from 5.0 x 10(-7) to 2.0 x 10(-5) M, with a detection limit of 1.5 x 10(-7) M (S/N= 3). The CIN/GCE was used for the determination of UA in samples with satisfactory results. The proposed CIN/GCE electrochemical sensing platform holds great promise for simple, rapid, and accurate detection of UA.