Porous graphitic carbon as a stationary phase in HPLC: Theory and applications

被引：138
|
作者：
Pereira, Luisa [1 ]
机构：
[1] Thermo Fisher Sci, Runcorn WA7 1PR, Cheshire, England
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2008年 / 31卷 / 11-12期
关键词：
electronic interaction chromatography; hypercarb; isomers; polar retention effect on graphite; polar solutes; retention mechanisms;
D O I：
10.1080/10826070802126429
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper gives an overview of the properties and behaviour of porous graphitic carbon (PGC) as a stationary phase in HPLC. Key applications areas that illustrate the capabilities of this chromatographic material to solve problem separations are reviewed. The retention mechanisms on this stationary phase for hydrophobic and polar solutes are described. PGCs' physical and chemical properties and the development of this unique chromatographic material are discussed. Over 140 references of applications of PGC in pharmaceutical, environmental, food safety, natural products, biochemical, clinical, and chemical warfare analysis are reviewed covering a range of solute properties.
引用
收藏
页码：1687 / 1731
页数：45
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