Preparation of β-amino esters by a chiral bronsted acid catalyzed Mannich-type reaction

被引：36
|
作者：
Itoh, Junji [1 ]
Fuchibe, Kohei [1 ]
Akiyama, Takahiko [1 ]
机构：
[1] Gakushuin Univ, Dept Chem, Toshima Ku, Tokyo 1718588, Japan
来源：
SYNTHESIS-STUTTGART | 2008年 / 08期
关键词：
chiral Bronsted acid; asymmetric synthesis; catalyst; Mannich-type reaction; beta-amino esters;
D O I：
10.1055/s-2008-1032017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Mannich-type reactions of ketene silyl acetals with aldimines proceeded smoothly under the influence of 10 mol% of a cyclic chiral phosphate derivative derived from (R)-BINOL as a chiral Bronsted acid catalyst to furnish P-amino esters with excellent enantioselectivities.
引用
收藏
页码：1319 / 1322
页数：4
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