Clickable rhodamine spirolactam based spontaneously blinking probe for super-resolution imaging

被引：22
|
作者：
Liu, Zengjin [1 ]
Zheng, Ying [2 ]
Xie, Ting [1 ]
Chen, Zihan [1 ]
Huang, Zhenlong [1 ,2 ]
Ye, Zhiwei [2 ]
Xiao, Yi [2 ]
机构：
[1] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Drug Res Ctr Integrated Tradit Chinese & Western, Luzhou 646000, Peoples R China
[2] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 12期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Super resolution imaging; Spontaneously blinking; pK(a); Rhodamine spirolactam; MICROSCOPY;
D O I：
10.1016/j.cclet.2021.04.038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Spontaneously blinking probe, which switches between dark and bright state without UV or external additives, is extremely attractive in super resolution imaging of live cells. Herein, a clickable rhodamine spirolactam probe, Atto565-Tet, is rationally constructed for spontaneously blinking after biorthogonal labelling and successfully applied to super resolution imaging of mitochondria and lysosomes. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
引用
收藏
页码：3862 / 3864
页数：3
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