Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene

被引：16

作者：

Garte, S

Popov, T

Georgieva, T

Bolognesi, C

Taioli, E

Bertazzi, P

Farmer, P

Merlo, DF

机构：

[1] UMDNJ, Sch Publ Hlth, New Brunswick, NJ 08903 USA

[2] Genet Res Inst, Milan, Italy

[3] Natl Ctr Hygiene, Sofia, Bulgaria

[4] IST, Genoa, Italy

[5] IRCCS, Osped Policlin, Milan, Italy

[6] Fdn Clin Lavoro, Milan, Italy

[7] Univ Leicester, Leicester, Leics, England

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2005年 / 153卷

关键词：

benzene; biomarkers; NQO1; genotype; DNA single strand breaks; petrochemical workers;

D O I：

10.1016/j.cbi.2005.03.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：247 / 251

页数：5

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