Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems

被引：16
|
作者：
Zhao, Qian [1 ]
Han, Bo [2 ]
Wang, Biao [1 ]
Leng, Hai-Jun [2 ]
Peng, Cheng [1 ,2 ]
Huang, Wei [1 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Minist Educ, Key Lab Standardizat Chinese Med, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China
来源：
RSC ADVANCES | 2015年 / 5卷 / 34期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC-SYNTHESIS; ALPHA; BETA-UNSATURATED ALDEHYDES; ACYL AZOLIUMS; MICHAEL ADDITION; ENANTIOSELECTIVE SYNTHESIS; TANDEM REACTIONS; MODIFIED ENALS; NHC CATALYSIS; ANNULATION; ACTIVATION;
D O I：
10.1039/c5ra01254f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two consecutive N-heterocyclic carbene (NHC) catalytic systems were combined in a one-pot cascade reaction for the assembly of aromatic aldehydes and 2-haloenals into a structurally complex gamma-lactone backbone. To our knowledge, this is the first report of NHC-catalyzed [3 + 2] annulation of alpha,beta-unsaturated acylazoliums with 1,2-bisnucleophiles.
引用
收藏
页码：26972 / 26976
页数：5
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