Deep eutectic solvent: a simple, environmentally benign reaction media for regioselective synthesis of 2,3,4-trisubstituted 1H-pyrroles

被引：29
|
作者：
Kalmode, Hanuman P. [1 ]
Vadagaonkar, Kamlesh S. [1 ]
Murugan, Kaliyappan [2 ]
Prakash, Sattey [3 ]
Chaskar, Atul C. [1 ,3 ]
机构：
[1] Inst Chem Technol, Dept Dyestuff Technol, Bombay 400019, Maharashtra, India
[2] Natl Taiwan Univ, Taipei 10617, Taiwan
[3] Univ Mumbai, Natl Ctr Nanosci & Nanotechnol, Bombay 400098, Maharashtra, India
来源：
RSC ADVANCES | 2015年 / 5卷 / 44期
关键词：
ONE-POT SYNTHESIS; HIGHLY EFFICIENT SYNTHESIS; IONIC LIQUIDS; POLYSUBSTITUTED PYRROLES; FUNCTIONALIZED PYRROLES; 1,3-DICARBONYL COMPOUNDS; BIOLOGICAL EVALUATION; 3-COMPONENT SYNTHESIS; SUBSTITUTED PYRROLES; SOLID CATALYST;
D O I：
10.1039/c5ra03270a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Choline hydroxide has been successfully employed as an efficient base as well as reaction media for the synthesis of 2,3,4-trisubstituted 1H-pyrroles from methyl 2-isocyanoacetate and alpha,beta-unsaturated ketones. The choline hydroxide used is inexpensive, non-toxic, recyclable and environmentally friendly. Mild reaction conditions and an easy workup procedure are the striking features of this protocol. This transformation proceeds through the 1,4-conjugate addition of methyl 2-isocyanoacetate with alpha,beta-unsaturated ketones followed by intramolecular cyclization-oxidation reaction.
引用
收藏
页码：35166 / 35174
页数：9
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