Coalescent angiogenesis-evidence for a novel concept of vascular network maturation

被引:29
|
作者
Nitzsche, Bianca [1 ,2 ,3 ,4 ,5 ]
Rong, Wen Wei [1 ,2 ,3 ,4 ]
Goede, Andrean [1 ,2 ,3 ,4 ]
Hoffmann, Bjoern [1 ,2 ,3 ,4 ]
Scarpa, Fabio [6 ]
Kuebler, Wolfgang M. [1 ,2 ,3 ,4 ,5 ]
Secomb, Timothy W. [7 ]
Pries, Axel R. [1 ,2 ,3 ,4 ,5 ]
机构
[1] Charite Univ Med Berlin, Berlin, Germany
[2] Free Univ Berlin, Berlin, Germany
[3] Humboldt Univ, Berlin, Germany
[4] Berlin Inst Hlth, Inst Physiol, Berlin, Germany
[5] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, D-10117 Berlin, Germany
[6] Univ Padua, Dept Informat Engn, Padua, Italy
[7] Univ Arizona, Dept Physiol, Tucson, AZ 85724 USA
关键词
Coalescent angiogenesis; Capillary mesh; Tissue islands; Intussusception; Splitting angiogenesis; Sprouting angiogenesis; Chorioallantoic membrane (CAM); Intravital microscopy; INTUSSUSCEPTIVE ANGIOGENESIS; GROWTH; MECHANISMS; MODELS; SYSTEM;
D O I
10.1007/s10456-021-09824-3
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Angiogenesis describes the formation of new blood vessels from pre-existing vascular structures. While the most studied mode of angiogenesis is vascular sprouting, specific conditions or organs favor intussusception, i.e., the division or splitting of an existing vessel, as preferential mode of new vessel formation. In the present study, sustained (33-h) intravital microscopy of the vasculature in the chick chorioallantoic membrane (CAM) led to the hypothesis of a novel non-sprouting mode for vessel generation, which we termed "coalescent angiogenesis." In this process, preferential flow pathways evolve from isotropic capillary meshes enclosing tissue islands. These preferential flow pathways progressively enlarge by coalescence of capillaries and elimination of internal tissue pillars, in a process that is the reverse of intussusception. Concomitantly, less perfused segments regress. In this way, an initially mesh-like capillary network is remodeled into a tree structure, while conserving vascular wall components and maintaining blood flow. Coalescent angiogenesis, thus, describes the remodeling of an initial, hemodynamically inefficient mesh structure, into a hierarchical tree structure that provides efficient convective transport, allowing for the rapid expansion of the vasculature with maintained blood supply and function during development.
引用
收藏
页码:35 / 45
页数:11
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