Systemic Therapy of Atopic Dermatitis: Welcome to the Revolution

被引：0

作者：

Eichenfield, Lawrence F. ^{[1
,2
,3
,4
]}

Gold, Linda F. Stein ^{[5
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dermatol & Pediat, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Dermatol, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Sch Med, Pediat & Adolescent Dermatol, La Jolla, CA 92093 USA

[4] Univ Calif, Rady Childrens Hosp, San Diego, CA USA

[5] Henry Ford Hlth Syst, Dermatol Res, Detroit, MI USA

来源：

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY | 2017年 / 36卷

关键词：

Atopic dermatitis; dupilumab; fezakinumab; JAK inhibitors; lebrikizumab; nemolizumab; systemic therapy; tralokinumab; PLACEBO; MANAGEMENT; DUPILUMAB; TRIAL;

D O I：

10.12788/j.sder.2017.051

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Until recently, systemic therapy of atopic dermatitis was limited to off-label use of immunomodulators, which can pose significant safety concerns, and treatment with systemic corticosteroids, not recommended in the most recent guidelines. The introduction of dupilumab in 2017 marked a major advance in systemic therapy for atopic dermatitis. It has demonstrated long-term efficacy in adults with moderate to severe disease, and is being studied in children. Several other biologic agents and "small molecules" with varying mechanisms of action are in phase 2 or 3 development. (C) 2017 published by Frontline Medical Communications

引用

页码：S103 / S105

页数：3

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