The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample

被引：19
|
作者：
Moruzzi, Sara [1 ]
Ogliari, Anna [1 ,2 ]
Ronald, Angelica [4 ]
Happe, Francesca [5 ]
Battaglia, Marco [1 ,2 ,3 ]
机构：
[1] Univ Vita Salute San Raffaele, Acad Ctr Study Behav Plast, I-20127 Milan, Italy
[2] Ist Sci San Raffaele, Milan, Italy
[3] Ist Sci Eugenio Medea, Dept Child Psychiat, Bosisio Parini, Italy
[4] Univ London, Dept Psychol Sci, Ctr Brain & Cognit Dev, London, England
[5] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2011年 / 41卷 / 12期
基金：
英国医学研究理事会;
关键词：
Clumsiness; Autistic traits; CBCL; Comorbidity; Twin study; DEVELOPMENTAL COORDINATION DISORDER; DEFICIT-HYPERACTIVITY DISORDER; CHILD-BEHAVIOR CHECKLIST; SPECTRUM DISORDERS; ASPERGERS-SYNDROME; ENVIRONMENTAL-INFLUENCES; MOTOR COORDINATION; SWEDISH CHILDREN; SHARED ETIOLOGY; IDENTIFICATION;
D O I：
10.1007/s10803-011-1199-8
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8-17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63.
引用
收藏
页码：1665 / 1674
页数：10
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