Linalyl Acetate Ameliorates Mechanical Hyperalgesia Through Suppressing Inflammation by TSLP/IL-33 Signaling

被引:8
|
作者
Lu, Ying-Yi [1 ,2 ,3 ]
Lu, Chun-Ching [4 ,5 ,6 ]
Huang, Chao-Lan [7 ,8 ]
Tsai, Hung-Pei [9 ]
Wang, Wei-Ting [10 ]
Zhang, Zi-Hao [11 ]
Wu, Chieh-Hsin [9 ,12 ,13 ]
机构
[1] Kaohsiung Vet Gen Hosp, Dept Dermatol, Kaohsiung 813, Taiwan
[2] Natl Sun Yat Sen Univ, Coll Med, Sch Med, Dept Postbaccalaureate Med, Kaohsiung 804, Taiwan
[3] Shu Zen Jr Coll Med & Management, Kaohsiung 821, Taiwan
[4] Natl Yang Ming Chiao Tung Univ Hosp, Dept Orthopaed & Traumatol, Yilan 260, Taiwan
[5] Natl Yang Ming Chiao Tung Univ, Sch Med, Dept Orthopaed, Taipei 112, Taiwan
[6] Taipei Vet Gen Hosp, Dept Orthopaed & Traumatol, Taipei 112, Taiwan
[7] Taipei Vet Gen Hosp, Dept Anesthesiol, Taipei 112, Taiwan
[8] Natl Yang Ming Chiao Tung Univ, Sch Med, Dept Anesthesiol, Taipei 112, Taiwan
[9] Kaohsiung Med Univ Hosp, Dept Surg, Div Neurosurg, 100,Tzyou 1st Rd, Kaohsiung 807, Taiwan
[10] Triserv Gen Hosp, Natl Def Med Ctr, Dept Radiol, Taipei 11490, Taiwan
[11] Xinle City Hosp, Dept Neurosurg, Xinle 050700, Hebei, Peoples R China
[12] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Surg, Kaohsiung 807, Taiwan
[13] Kaohsiung Med Univ, Ctr Big Data Res, Kaohsiung, Taiwan
关键词
Inflammation; linalyl acetate (LA); interleukin (IL)-33; sciatic nerve injury (SNI); thymic stromal lymphopoietin (TSLP); THYMIC STROMAL LYMPHOPOIETIN; NECROSIS-FACTOR-ALPHA; DORSAL-ROOT GANGLION; NEUROPATHIC PAIN; EXPRESSION; CYTOKINES; CONTRIBUTES; MICROGLIA; APOPTOSIS; PROFILE;
D O I
10.1007/s11064-022-03763-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neuropathic pain is a debilitating chronic disorder, significantly causing personal and social burdens, in which activated neuroinflammation is one major contributor. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 is important for chronic inflammation. Linalyl acetate (LA) is main component of lavender oil with an anti-inflammatory property through TSLP signaling. The aim of the study is to investigate how LA regulates mechanical hyperalgesia after sciatic nerve injury (SNI). Adult Sprague-Dawley male rats were separated into 3 groups: control group, SNI group and SNI with LA group. LA was administrated intraperitoneally one day before SNI. Pain behavior test was evaluated through calibration forceps testing. Ipsilateral sciatic nerves (SNs), dorsal root ganglions (DRGs) and spinal cord were collected for immunofluorescence staining and Western blotting analyses. SNI rats were more sensitive to hyperalgesia response to mechanical stimulus since operation, which was accompanied by spinal cord glial cells reactions and DRG neuro-glial interaction. LA could relieve the pain sensation, proinflammatory cytokines and decrease the expression of TSLP/TSLPR complex. Also, LA could reduce inflammation through reducing IL-33 signaling. This study is the first to indicate that LA can modulate pain through TSLP/TSLPR and IL-33 signaling after nerve injury.
引用
收藏
页码:3805 / 3816
页数:12
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