Environmental enrichment with nesting material accelerates wound healing in isolation-reared rats

被引：11
|
作者：
Vitalo, Antonia G. [2 ,5 ,6 ]
Gorantla, Sasikanth [2 ,5 ,6 ]
Fricchione, Jonathan G. [2 ,5 ,6 ]
Scichilone, John M. [2 ,5 ,6 ]
Camacho, Jennifer [7 ]
Niemi, Steven M. [7 ,11 ]
Denninger, John W. [2 ,5 ,8 ]
Benson, Herbert [4 ,5 ,10 ]
Yarmush, Martin L. [1 ,3 ,6 ,9 ]
Levine, John B. [2 ,3 ,5 ,6 ,8 ]
机构：
[1] Shriners Burns Hosp, Ctr Engn & Med, Boson, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Benson Henry Inst Mind Body Med, Boston, MA 02114 USA
[6] Massachusetts Gen Hosp, Ctr Engn & Med, Boston, MA 02114 USA
[7] Massachusetts Gen Hosp, Ctr Comparat Med, Boston, MA 02114 USA
[8] Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA
[9] Harvard Univ, Sch Med, Dept Surg, Cambridge, MA 02138 USA
[10] Harvard Univ, Sch Med, Dept Med, Cambridge, MA 02138 USA
[11] Harvard Univ, Sch Med, Dept Pathol, Cambridge, MA 02138 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2012年 / 226卷 / 02期
关键词：
Environmental enrichment; Isolation rearing; Wound healing; Bedding; Nesting; MEDIAL PREFRONTAL CORTEX; PROINFLAMMATORY CYTOKINE PRODUCTION; DEPRESSIVE-LIKE BEHAVIOR; EARLY GENE-EXPRESSION; SOCIAL-ISOLATION; PREPULSE INHIBITION; SUCROSE CONSUMPTION; SPRAGUE-DAWLEY; STRESS; EXPERIENCE;
D O I：
10.1016/j.bbr.2011.09.038
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Early enrichment (EE) programs provide a well-established approach to mitigate the deleterious effects of childhood adversity. To better understand the therapeutic features of EE, in the current study we compared the effect of two forms of nesting material on isolation reared (IR) rats. We found that both materials, absent of social and any other physical enrichment, significantly improved wound healing rates. The results suggest that this animal model may provide useful insights into the critical components of EE. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：606 / 612
页数：7
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