The Indications for Hepatectomy for Multinodular Hepatocellular Carcinoma: Experience from a Single Institution

被引:1
|
作者
Zhou, Yuan-da [1 ]
Li, Hui-kai [1 ]
Cui, Yun-long [1 ]
Zhang, Ti [1 ]
Li, Qiang [1 ]
机构
[1] Tianjin Med Univ, Canc Inst & Hosp, Dept Hepatobiliary Canc, Key Lab Canc Prevent & Therapy, Tianjin 300000, Peoples R China
关键词
Hepatectomy; Prognosis; Hepatocellular carcinoma; Multinodular; PERCUTANEOUS RADIOFREQUENCY ABLATION; PREOPERATIVE PLATELET COUNT; LIVER RESECTION; MULTIINSTITUTIONAL ANALYSIS; SURGICAL RESECTION; SELECTING PATIENTS; MILAN CRITERIA; TRANSPLANTATION; MANAGEMENT; SURVIVAL;
D O I
10.1159/000370128
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Aims: This study was conducted in order to investigate the indications for hepatecomy for multinodular hepatocellular carcinoma (MNHCC) in single institution. Methods: We retrospectively analyzed the medical records from 55 MNHCC patients, mainly with Child-Pugh A liver function, who underwent hepatectomy from January 2006 to December 2008. Both short-and long-term outcomes were analyzed. In addition, the prognostic significance of clinicopathological factors on overall survival (OS) was investigated by univariate analysis using the log-rank test. A Cox proportional hazards model was used in a subsequent multivariate analysis. Results: The perioperative morbidity rate (grade II or higher) was 18.2% (n = 10), and the in-hospital mortality rate was 3.6%. The median OS was 23.9 months (range, 2.5-84 months), whereas the median disease-free survival was 8.75 months (range, 1-65 months). Independent prognostic risk factors of 5-year OS included the number of tumors >2 (p = 0.032) and gross morphology indicating multiple tumor nodules scattered throughout the liver (p = 0.009). Conclusions: The postoperative morbidity and mortality rates were acceptable. The number of tumors >2 and gross morphology indicating multiple tumor nodules scattered throughout the liver were independent prognostic risk factors for patients with MNHCC after hepatectomy. Patients with both of these features had a very poor prognosis and were not considered suitable for surgery. (C) 2015 S. Karger AG, Basel
引用
收藏
页码:82 / 89
页数:8
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