Rapid repolarization of the action potential due to increased transient outward current limits Ca2+ influx while preserving excitation-contraction coupling in cardiac specific Na+/Ca2+ exchanger knockout mice

被引：0
|
作者：
Pott, C
Ren, XY
Philipson, KD
Goldhaber, JI
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Cardiol, Los Angeles, CA 90024 USA
来源：
CIRCULATION | 2005年 / 112卷 / 17期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
172
引用
收藏
页码：U64 / U65
页数：2
相关论文
共 46 条
  • [21] Na+/Ca2+ exchanger 2-heterozygote knockout mice display increased relaxation in gastric fundus
    Hayashi, Satomi
    Azuma, Yasu-Taka
    Kita, Satomi
    Nakajima, Hidemitsu
    Iwamoto, Takahiro
    Takeuchi, Tadayoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124 : 108P - 108P
  • [22] Activation of reverse Na+- Ca2+ exchanger by skeletal Na+ channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes
    Torres, Natalia S.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2021, 320 (02): : H593 - H603
  • [23] Profile of L-Type Ca2+ Current and Na+/Ca2+ Exchange Current during Cardiac Action Potential in Ventricular Myocytes
    Banyasz, Tamas
    Horvath, Balazs
    Jian, Zhong
    Izu, Leighton T.
    Chen-Izy, Ye
    BIOPHYSICAL JOURNAL, 2012, 102 (03) : 128A - 128A
  • [24] Profile of L-type Ca2+ current and Na+/Ca2+ exchange current during cardiac action potential in ventricular myocytes
    Banyasz, Tamas
    Horvath, Balazs
    Jian, Zhong
    Izu, Leighton T.
    Ye Chen-Izu
    HEART RHYTHM, 2012, 9 (01) : 134 - 142
  • [25] Voltage dependence of cardiac excitation-contraction coupling -: Unitary Ca2+ current amplitude and open channel probability
    Altamirano, Julio
    Bers, Donald M.
    CIRCULATION RESEARCH, 2007, 101 (06) : 590 - 597
  • [26] CaMKII Regulation of the Dynamic L-Type Ca2+ Current and Na+/Ca2+ Exchange Current During Action Potential in Cardiac Myocytes
    Banyasz, Tamas
    Izu, Leighton T.
    Chen-Izu, Ye
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 334A - 334A
  • [27] Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes
    Maack, Christoph
    Cortassa, Sonia
    Aon, Miguel A.
    Ganesan, Anand N.
    Liu, Ting
    O'Rourke, Brian
    CIRCULATION RESEARCH, 2006, 99 (02) : 172 - 182
  • [28] PARTIAL INHIBITION OF CA2+ CURRENT BY METHOXYVERAPAMIL (D600) REVEALS SPATIAL NONUNIFORMITIES IN [CA2+](I) DURING EXCITATION-CONTRACTION COUPLING IN CARDIAC MYOCYTES
    CHENG, H
    CANNELL, MB
    LEDERER, WJ
    CIRCULATION RESEARCH, 1995, 76 (02) : 236 - 241
  • [29] Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice
    Ren, Chongyu
    Zhang, Jin
    Philipson, Kenneth D.
    Kotlikoff, Michael I.
    Blaustein, Mordecai P.
    Matteson, Donald R.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2010, 298 (05): : H1484 - H1491
  • [30] Increased oxidative stress alters excitation-contraction coupling and increases Na+-Ca2+ exchanger expression in cardiac myocytes
    Luo, JZ
    Xuan, YT
    Prabhu, SD
    CIRCULATION, 2001, 104 (17) : 247 - 248
12345