Micronucleus Assay: The State of Art, and Future Directions

被引：159
|
作者：
Sommer, Sylwester [1 ]
Buraczewska, Iwona [1 ]
Kruszewski, Marcin [1 ,2 ]
机构：
[1] Inst Nucl Chem & Technol, Ctr Radiobiol & Biol Dosimetry, Dorodna 16, PL-03195 Warsaw, Poland
[2] Inst Rural Hlth, Dept Mol Biol & Translat Res, Jaczewskiego 2, PL-20090 Lublin, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 04期
关键词：
micronucleus assay; genotoxicity; biomonitoring; biological dosimetry; genotoxicity tests; buccal cells; lymphocytes; FLOW-CYTOMETRIC ANALYSIS; DOUBLE-MINUTE CHROMOSOMES; CYTOKINESIS-BLOCK METHOD; AUTOMATED IMAGE-ANALYSIS; BONE-MARROW-CELLS; PERIPHERAL-BLOOD; IN-VITRO; DNA-DAMAGE; IONIZING-RADIATION; HUMAN-LYMPHOCYTES;
D O I：
10.3390/ijms21041534
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During almost 40 years of use, the micronucleus assay (MN) has become one of the most popular methods to assess genotoxicity of different chemical and physical factors, including ionizing radiation-induced DNA damage. In this minireview, we focus on the position of MN among the other genotoxicity tests, its usefulness in different applications and visibility by international organizations, such as International Atomic Energy Agency, Organization for Economic Co-operation and Development and International Organization for Standardization. In addition, the mechanism of micronuclei formation is discussed. Finally, foreseen directions of the MN development are pointed, such as automation, buccal cells MN and chromothripsis phenomenon.
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收藏
页数：19
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