Whole-genome analysis of a human rabies virus from Sri Lanka

被引：21

作者：

Matsumoto, Takashi ^{[2
]}

Ahmed, Kamruddin ^{[1
]}

Wimalaratne, Omala ^{[3
]}

Yamada, Kentaro ^{[1
]}

Nanayakkara, Susilakanthi ^{[3
]}

Perera, Devika ^{[3
]}

Karunanayake, Dushantha ^{[3
]}

Nishizono, Akira ^{[2
]}

机构：

[1] Oita Univ, Res Promot Project, Oita 8795593, Japan

[2] Oita Univ, Dept Microbiol, Fac Med, Yufu, Japan

[3] Med Res Inst, Rabies Lab, Colombo, Sri Lanka

来源：

ARCHIVES OF VIROLOGY | 2011年 / 156卷 / 04期

关键词：

STRAND RNA VIRUSES; DYNEIN LIGHT-CHAIN; MATRIX PROTEIN; ANTIGENIC SITES; IN-VITRO; NUCLEOTIDE-SEQUENCE; NUCLEOPROTEIN GENE; SYNTHETIC PEPTIDES; ESCHERICHIA-COLI; VACCINE STRAIN;

D O I：

10.1007/s00705-010-0905-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The complete genome sequence of a human rabies virus, strain H-08-1320, from Sri Lanka was determined and compared with other rabies viruses. The size of the genome was 11,926 nt, and it was composed of a 58-nucleotide 3' leader, five protein genes - N (1353 nt), P (894 nt), M (609 nt), G (1575 nt), and L (6387 nt) - and a 70-nt 5' trailer. The intergenic region G-L contained 515 nt. The sizes of the nucleoprotein, phosphoprotein, matrix-protein, glycoprotein and large-protein was 450, 296, 202, 524 and 2,128 residues, respectively. The phosphoprotein and large protein were one amino acid shorter and longer, respectively, than those of most rabies viruses. The glycoprotein of H-08-1320 had a unique amino acid substitution at antigenic site I. Whole-genome phylogenetic analysis showed that strain H-08-1320 formed an independent lineage and did not cluster with rabies viruses from other countries.

引用

页码：659 / 669

页数：11

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