Pharmacological effects of berberine on mood disorders

被引：67

作者：

Fan, Jie ^{[1
]}

Zhang, Kun ^{[1
]}

Jin, Yang ^{[1
]}

Li, Bingjini ^{[1
]}

Gao, Shuohui ^{[2
]}

Zhu, Jiaming ^{[1
]}

Cui, Ranji ^{[1
]}

机构：

[1] Jilin Univ, Jilin Prov Key Lab Mol & Chem Genet, Hosp 2, Changchun, Jilin, Peoples R China

[2] Jilin Univ, Dept Gastrointestinal Colorectal Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2019年 / 23卷 / 01期

关键词：

anxiety; berberine; bipolar disorder; depression; mechanism; pharmacology; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; STAR-ASTERISK-D; NF-KAPPA-B; SIGMA-1; RECEPTORS; IN-VITRO; ISOQUINOLINE ALKALOIDS; MAJOR DEPRESSION; PC12; CELLS; RAT MODEL;

D O I：

10.1111/jcmm.13930

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Berberine, a natural isoquinoline alkaloid, is used in herbal medicine and has recently been shown to have efficacy in the treatment of mood disorders. Furthermore, berberine modulates neurotransmitters and their receptor systems within the central nervous system. However, the detailed mechanisms of its action remain unclear. This review summarizes the pharmacological effects of berberine on mood disorders. Therefore, it may be helpful for potential application in the treatment of mood disorders.

引用

页码：21 / 28

页数：8

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