Benzimidazole tethered pyrrolo [3,4-b] quinoline with broad-spectrum activity against fungal pathogens

被引：28
|
作者：
Villa, Pedro [1 ]
Arumugam, Natarajan [2 ]
Almansour, Abdulrahman I. [2 ]
Kumar, Raju Suresh [2 ]
Mahalingam, S. M. [3 ]
Maruoka, Keiji [4 ]
Thangamani, Shankar [5 ]
机构：
[1] Midwestern Univ, Glendale, AZ 85308 USA
[2] King Saud Univ, Dept Chem, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia
[3] SRM Inst Sci & Technol, Dept Chem, Kattankulathur 603203, Kancheepuram, India
[4] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan
[5] Midwestern Univ, Dept Pathol & Populat Med, Coll Vet Med, 19555 N 59th Ave, Glendale, AZ 85308 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2019年 / 29卷 / 05期
关键词：
Antifungal agent; Toxicity; Benzimidazole fused pyrroloquinoline; Povarov reaction; BLOOD-STREAM INFECTIONS; CANDIDA-ALBICANS; CANCER; SURVEILLANCE;
D O I：
10.1016/j.bmcl.2019.01.006
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fungal infections caused by Candida and Cryptococcus are particularly dangerous for immunocompromised individuals. In this study, we identified that benzimidazole fused pyrrolo [3,4-b]quinoline compounds have potent antifungal activity against several clinical isolates of pathogenic fungal strains. Specifically, the compound 6a did not show cytotoxicity against mammalian cells at a concentration that inhibits the growth of fungal strains. In addition, the compound 6a also significantly reduced the metabolic activity of fungal cells in the Candida albicans biofilms. Collectively, our results indicate that benzimidazole fused quinoline compounds have a potential to develop as an antifungal agents.
引用
收藏
页码：729 / 733
页数：5
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