Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

被引：36

作者：

Dubee, Vincent ^{[1
,2
,3
,4
]}

Soroka, Daria ^{[1
,2
,3
]}

Cortes, Melanie ^{[1
,2
,3
]}

Lefebvre, Anne-Laure ^{[1
,2
,3
]}

Gutmann, Laurent ^{[1
,2
,3
,5
]}

Hugonnet, Jean-Emmanuel ^{[1
,2
,3
]}

Arthur, Michel ^{[1
,2
,3
]}

Mainardi, Jean-Luc ^{[1
,2
,3
,5
]}

机构：

[1] INSERM, LRMA, Ctr Rech Cordeliers, Equipe 12,UMR S 1138, Paris, France

[2] Univ Paris 06, Sorbonne Univ, Ctr Rech Cordeliers, UMR S 1138, Paris, France

[3] Univ Paris 05, Ctr Rech Cordeliers, Sorbonne Paris Cite, UMR S 1138, Paris, France

[4] Hop St Antoine, AP HP, Serv Reanimat Med, F-75571 Paris, France

[5] Hop Europeen Georges Pompidou, AP HP, Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 05期

关键词：

MASSILIENSE; CEPHALOSPORIN; INFECTIONS; ACID;

D O I：

10.1128/AAC.05080-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The production of beta-lactamases BlaMab and BlaC contributes to beta-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from >= 256 to 16 to 64 mu g/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.

引用

页码：2938 / 2941

页数：4

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