In vitro cytotoxicity and antibacterial studies of ruthenium(II) DMSO complexes with S-allyldithiocarbazate

The ruthenium(II) DMSO complexes with formula [RuCl(DMSO)(3)L-1](1) and [RuCl(DMSO)(3)L-2](2) had been synthesised. The newly synthesised complexes are characterised by elemental analysis, UV-VIS, FT-IR, NMR and ESI-MS spectroscopy. The spectral and analytical data of the complexes 1 and 2 supports well with the molecular formulae proposed. The in vitro cytotoxicity of these complexes evaluated using MTT assay indicate that the above complexes are more toxic against Hela cervical cancer cell line, but significantly less toxic against the normal Vero cell line. Furthermore, the antibacterial activity of the complexes 1 and 2 against S. aureus and E. Coli had also been tested and compared with standard streptomycin.