Sarcoidosis following alemtuzumab treatment for multiple sclerosis

被引：25
|
作者：
Willis, Mark D. [1 ,2 ,3 ]
Hope-Gill, Ben [4 ]
Flood-Page, Patrick [5 ]
Joseph, Fady [6 ]
Needham, Ed [7 ]
Jones, Joanne [7 ]
Coles, Alasdair [7 ]
Robertson, Neil P. [1 ,2 ,3 ]
机构：
[1] Cardiff Univ, Inst Psychol Med & Clin Neurosci, Heath Pk, Cardiff CF14 4XN, S Glam, Wales
[2] Univ Hosp Wales, Heath Pk, Cardiff CF14 4XN, S Glam, Wales
[3] Univ Hosp Wales, Dept Neurol, Cardiff, S Glam, Wales
[4] Univ Hosp Llandough, Dept Resp Med, Llandough, Wales
[5] Royal Gwent Hosp, Dept Resp Med, Newport, Gwent, Wales
[6] Royal Gwent Hosp, Dept Neurol, Newport, Gwent, Wales
[7] Addenbrookes Hosp, Dept Neurol, Cambridge, England
来源：
MULTIPLE SCLEROSIS JOURNAL | 2018年 / 24卷 / 13期
关键词：
Multiple sclerosis; alemtuzumab; IMMUNE RECONSTITUTION;
D O I：
10.1177/1352458518790391
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Despite proven efficacy of alemtuzumab in multiple sclerosis (MS), approximately 50% of individuals will develop a new autoimmune disease following treatment. To date, these have largely been antibody mediated and organ specific (primarily affecting the thyroid gland). In a retrospective case series of 187 patients from two UK specialist centres (Cardiff and Cambridge) followed up for a median of 10 years, we report three (1.6%) cases of sarcoidosis following alemtuzumab treatment of MS. This report increases the spectrum of auto-inflammatory disease following alemtuzumab and should be considered by clinicians when using this therapeutic agent for MS.
引用
收藏
页码：1779 / 1782
页数：4
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