Novel Biologics for the Treatment of Pediatric Severe Asthma

被引：1

作者：

Licari, Amelia ^{[1
,2
]}

Castagnoli, Riccardo ^{[2
]}

Tondina, Enrico ^{[2
]}

Testa, Giorgia ^{[1
]}

Parisi, Giuseppe Fabio ^{[3
]}

Marseglia, Alessia ^{[2
]}

Brambilla, Ilaria ^{[1
,2
]}

Marseglia, Gian Luigi ^{[1
,2
]}

机构：

[1] Fdn IRCCS Policlin San Matteo, SC Pediat, Pavia, Italy

[2] Univ Pavia, Dept Pediat, Pavia, Italy

[3] Univ Catania, Dept Clin & Expt Med, Catania, Italy

来源：

CURRENT RESPIRATORY MEDICINE REVIEWS | 2019年 / 15卷 / 03期

关键词：

Benralizumab; children; dupilumab; mepolizumab; omalizumab; reslizumab; severe asthma; SEVERE EOSINOPHILIC ASTHMA; SEVERE ALLERGIC-ASTHMA; ANTI-IGE; IMMUNOGLOBULIN-E; DOUBLE-BLIND; AIRWAY INFLAMMATION; MONOCLONAL-ANTIBODY; QGE031; LIGELIZUMAB; RANDOMIZED-TRIAL; SERUM IGE;

D O I：

10.2174/1573398X15666190521111816

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Estimated to represent less than 5% of all asthmatic patients, children with severe asthma experience troublesome persistent symptoms, life-threatening attacks and side effects by oral corticosteroid treatment, that significantly impact on the quality of life and on economic costs. An accurate understanding of the mechanisms of the disease has been crucial for the discovery and development of biological therapies, for which children with severe asthma are candidates. The aim of this review is to discuss the use of approved biologics for severe asthma, providing updated evidence of novel targeted therapies in the pediatric age range.

引用

页码：195 / 204

页数：10

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