Serological hepatitis B virus (HBV) activity in patients with HBV infection and B-cell non-Hodgkin's lymphoma

被引:16
|
作者
Zhou, Xiang [1 ,2 ]
Wuchter, Patrick [3 ]
Egerer, Gerlinde [1 ]
Kriegsmann, Mark [4 ]
Kommoss, Felix K. F. [4 ]
Witzens-Harig, Mathias [1 ]
Kriegsmann, Katharina [1 ]
机构
[1] Heidelberg Univ, Heidelberg Univ Hosp, Dept Internal Med 5, Heidelberg, Germany
[2] Univ Wurzburg, Wurzburg Univ Hosp, Dept Internal Med 2, Wurzburg, Germany
[3] Heidelberg Univ, Med Fac Mannheim, Inst Transfus Med & Immunol, German Red Cross Blood Serv Baden Wurttemberg Hes, Mannheim, Germany
[4] Heidelberg Univ, Heidelberg Univ Hosp, Insititue Pathol, Heidelberg, Germany
关键词
B-NHL; HBV; viral infection; C-VIRUS; HIGH PREVALENCE; RECOMMENDATIONS; EPIDEMIOLOGY; REACTIVATION; PROPHYLAXIS; EXPRESSION; PREVENTION; MUTATION; RISK;
D O I
10.1111/ejh.13388
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Previous epidemiological studies suggest an association between hepatitis B virus (HBV) infection and B-cell non-Hodgkin lymphoma (B-NHL). The aim of our study was to evaluate clinical characteristics and serological indicators of HBV activity in patients who were diagnosed with both HBV infection and indolent or aggressive B-NHL. Methods Seventy-two patients with current or resolved HBV infection and B-NHL were identified between 2000 and 2017 at our institution. Results Forty-five (63%) and 27 (37%) patients were identified with aggressive and indolent B-NHL, respectively. In indolent B-NHL, the proportion of HBsAg-positive patients was significantly higher compared with aggressive B-NHL (59% vs 38%, P = .03). HBV-DNA levels were significantly higher in patients with indolent compared to aggressive B-NHL (P = .01). In the subgroup analyzes of follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL), the rate of HBsAg positivity in FL is significantly higher than that in DLBCL (83% vs 44%, P = .04), and HBV-DNA levels were significantly higher in FL compared with DLBCL (P = .007). Conclusion Our results suggest that serological HBV activity is higher in patients with both HBV infection and indolent B-NHL compared to those with aggressive B-NHL.
引用
收藏
页码:469 / 475
页数:7
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