Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

被引：14

作者：

Tan, E. K. ^{[3
,4
,5
]}

Lu, C. S. ^{[1
,2
]}

Peng, R. ^{[6
]}

Teo, Y. Y. ^{[13
]}

Wu-Chou, Y. H. ^{[2
,7
]}

Chen, R. S. ^{[1
,2
]}

Weng, Y. H. ^{[1
,2
]}

Chen, C. M. ^{[1
,2
]}

Fung, H. C. ^{[1
,2
]}

Tan, L. C. ^{[3
,4
]}

Zhang, Z. J. ^{[6
]}

An, X. K. ^{[6
]}

Lee-Chen, G. J. ^{[9
]}

Lee, M. C. ^{[10
]}

Fook-Chong, S. ^{[3
,4
]}

Burgunder, J. M. ^{[11
,12
]}

Wu, R. M. ^{[8
]}

Wu, Y. R. ^{[1
,2
]}

机构：

[1] Chang Gung Univ, Chang Gung Mem Hosp, Dept Neurol, Taipei, Taiwan

[2] Chang Gung Univ, Coll Med, Taipei, Taiwan

[3] Singapore Gen Hosp, Natl Inst Neurosci, Dept Neurol, Singapore 0316, Singapore

[4] Singapore Gen Hosp, Natl Inst Neurosci, Dept Clin Res, Singapore 0316, Singapore

[5] Duke NUS Grad Med Sch, Singapore, Singapore

[6] Sichuan Univ, W China Hosp, Dept Neurol, Chengdu 610064, Peoples R China

[7] Chang Gung Univ, Chang Gung Mem Hosp, Human Mol Genet Lab, Taipei, Taiwan

[8] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Neurol, Taipei 10764, Taiwan

[9] Natl Taiwan Normal Univ, Dept Life Sci, Taipei, Taiwan

[10] Cathay Gen Hosp, Dept Neurol, Taipei, Taiwan

[11] Univ Bern, Dept Neurol, Bern, Switzerland

[12] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore

[13] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX1 2JD, England

来源：

NEUROBIOLOGY OF AGING | 2010年 / 31卷 / 12期

基金：

英国医学研究理事会;

关键词：

Parkinson's disease; Polymorphism; UCHL1; SUSCEPTIBILITY GENE; S18Y POLYMORPHISM; UCH-L1; GENE; ASSOCIATION;

D O I：

10.1016/j.neurobiolaging.2008.11.008

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p = 0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99(95% CI 0.84-1.16, p = 0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p = 0.816) were not significantly associated with PD. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：2194 / 2196

页数：3

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