Immunohistochemical characterization of normal canine Merkel cells

被引：0

作者：

Ramírez, GA ^{[1
]}

Herráez, P ^{[1
]}

Andrada, M ^{[1
]}

Fernández, A ^{[1
]}

Castro, P ^{[1
]}

de los Monteros, AE ^{[1
]}

机构：

[1] Univ Las Palmas Gran Canaria, Fac Vet, Dept Comparat Pathol, Las Palmas Gran Canaria, Spain

来源：

MERKEL CELL: STRUCTURE-DEVELOPMENT-FUNCTION-CANCEROGENESIS | 2003年

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cutaneous Merkel cells (MCs) have been well documented in humans, but less in other mammals. In dogs, there are only a few references about immunohistochemical characterization of MCs. We present the immunohistochemical profile of MCs in the dog for the most reliable antibodies used in human medicine. Tissue samples from several locations were obtained from five adult dogs of both sexes and different age and breed, fixed in 10% buffered formalin, embedded in paraffin wax and cut in 3-mum tissue sections. The ABC method was used with different poly- and monoclonal antibodies. Positive immunoreaction was found in MCs of hair follicles, skin and mucosae of several locations in each dog studied for anticytokeratins 8, 18 and 20, anti-neurofilaments, anti-chromogranin A, anti-neuron-specific enolase, and anti-synaptophysin. Immunoreaction was always cytoplasmic with differences in intensity, pattern of intracytoplasmic distribution and reaction type. Other cytokeratins, anti-S100 protein, anti-vimentin and anti-glial fibrillary acid protein were absent in canine normal MCs.

引用

页码：49 / 55

页数：7

共 50 条

[41] MORPHOMETRIC CHARACTERIZATION OF THE HUMAN NEUROENDOCRINE MERKEL CELLS
BEIRAS, A
GARCIACABALLERO, T
FERNANDEZREDONDO, V
GALLEGO, R
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 88 (06) : 766 - 768
[42] Characterization of human Merkel cells at various locations
Eispert, A
Brandner, JM
Houdek, P
Wladykowski, E
Moll, I
EXPERIMENTAL DERMATOLOGY, 2006, 15 (03) : 249 - 249
[43] Immunohistochemical characterization of HSP, α-MSH, Merkel cells and neuronal markers in acute UV dermatitis and acute contact dermatitis in vivo
C. Bayerl
J. Lauk
I. Moll
E. G. Jung
Inflammation Research, 1997, 46 : 409 - 411
[44] IMMUNOHISTOCHEMICAL CHARACTERIZATION OF EPITHELIOD CELLS
KNOLLE, J
ACTA HISTOCHEMICA, 1988, : 159 - 164
[45] Immunohistochemical Expression of FXR1 in Canine Normal Tissues and Melanomas
Nordio, Laura
Marques, Andreia T.
Lecchi, Cristina
Luciano, Alberto M.
Stefanello, Damiano
Giudice, Chiara
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2018, 66 (08) : 585 - 593
[46] PEANUT AGGLUTININ LECTIN IMMUNOHISTOCHEMICAL STAINING OF NORMAL AND NEOPLASTIC CANINE TISSUES
HAINES, DM
VETERINARY PATHOLOGY, 1993, 30 (04) : 333 - 342
[47] Immunohistochemical localization of estrogen receptor in the normal canine female genital tract
DeCock, H
Ducatelle, R
Logghe, JP
DOMESTIC ANIMAL ENDOCRINOLOGY, 1997, 14 (03) : 133 - 147
[48] Immunohistochemical expression of estrogen receptor β in normal and tumoral canine mammary glands
De Las Mulas, JM
Ordás, J
Millán, MY
Chacón, F
De Lara, M
De Los Monteros, AE
Reymundo, C
Jover, A
VETERINARY PATHOLOGY, 2004, 41 (03) : 269 - 272
[49] Expression and characterization of the catalytic subunit of telomerase in normal and cataractous canine lens epithelial cells
Colitz, Carmen Maria Helena
Barden, Curtis Andrew
Lu, Ping
Chandler, Heather Lynn
MOLECULAR VISION, 2006, 12 (119-21): : 1067 - 1076
[50] Immunohistochemical Characterization of Canine Oral Papillary Squamous Cell Carcinoma
Thaiwong, Tuddow
Sledge, Dodd G.
Collins-Webb, Alexandra
Kiupel, Matti
VETERINARY PATHOLOGY, 2018, 55 (02) : 224 - 232

← 1 2 3 4 5 →