Microneedles for Drug Delivery via the Gastrointestinal Tract

被引:141
|
作者
Traverso, Giovanni [1 ,2 ,3 ]
Schoellhammer, Carl M. [2 ,3 ]
Schroeder, Avi [3 ,4 ]
Maa, Ruby [2 ]
Lauwers, Gregory Y. [5 ]
Polat, Baris E. [2 ,3 ]
Anderson, Daniel G. [2 ,3 ,6 ,7 ]
Blankschtein, Daniel [2 ]
Langer, Robert [2 ,3 ,6 ,7 ]
机构
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Gastroenterol, Boston, MA USA
[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[3] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
[4] Technion Israel Inst Technol, Dept Chem Engn, IL-32000 Haifa, Israel
[5] Harvard Univ, Sch Med, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA
[6] MIT, Inst Med Engn & Sci, Cambridge, MA 02139 USA
[7] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA
关键词
mucosal drug delivery; gastrointestinal; macromolecular drug delivery; oral drug delivery; membrane transport; microneedles; pill; drug delivery systems; INGESTED FOREIGN-BODIES; TRANSDERMAL DELIVERY; IN-VIVO; INSULIN; MANAGEMENT; TRANSIT; PIGS;
D O I
10.1002/jps.24182
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Both patients and physicians prefer the oral route of drug delivery. The gastrointestinal (GI) tract, though, limits the bioavailability of certain therapeutics because of its protease and bacteria-rich environment as well as general pH variability from pH 1 to 7. These extreme environments make oral delivery particularly challenging for the biologic class of therapeutics. Here, we demonstrate proof-of-concept experiments in swine that microneedle-based delivery has the capacity for improved bioavailability of a biologically active macromolecule. Moreover, we show that microneedle-containing devices can be passed and excreted from the GI tract safely. These findings strongly support the success of implementation of microneedle technology for use in the GI tract. (c) 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:362-367, 2015
引用
收藏
页码:362 / 367
页数:6
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