Cerebral acetylcholine esterase activity in mild cognitive impairment

被引：49
|
作者：
Herholz, K [1 ]
Weisenbach, S
Kalbe, E
Diederich, NJ
Heiss, WD
机构：
[1] Univ Cologne, Dept Neurol, Cologne, Germany
[2] Ctr Hosp, Luxembourg, Luxembourg
[3] Max Planck Inst Neurol Res, Cologne, Germany
来源：
NEUROREPORT | 2005年 / 16卷 / 13期
关键词：
acetylcholine esterase; Alzheimer's disease; longitudinal study; mild cognitive impairment (MCI); positron emission tomography;
D O I：
10.1097/01.wnr.0000177007.21732.7b
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Mild cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment.
引用
收藏
页码：1431 / 1434
页数：4
相关论文
共 50 条
  • [21] Translating cognitive and everyday activity deficits into cognitive interventions in mild dementia and mild cognitive impairment
    Giebel, Clarissa
    Challis, David
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2015, 30 (01) : 21 - 31
  • [22] Myelin and Physical Activity in Older Adults With Cerebral Small Vessel Disease and Mild Cognitive Impairment
    Silva, Narlon C. Boa Sorte
    Dao, Elizabeth
    Hsu, Chun Liang
    Tam, Roger C.
    Lam, Kevin
    Alkeridy, Walid
    Laule, Cornelia
    Vavasour, Irene M.
    Stein, Ryan G.
    Liu-Ambrose, Teresa
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2023, 78 (03): : 545 - 553
  • [23] Cerebral microbleeds in patients with mild cognitive impairment and small vessel disease: The Vascular Mild Cognitive Impairment (VMCI)-Tuscany study
    Valenti, Raffaella
    Del Bene, Alessandra
    Poggesi, Anna
    Ginestroni, Andrea
    Salvadori, Emilia
    Pracucci, Giovanni
    Ciolli, Laura
    Marini, Sandro
    Nannucci, Serena
    Pasi, Marco
    Pescini, Francesca
    Diciotti, Stefano
    Orlandi, Giovanni
    Cosottini, Mirco
    Chiti, Alberto
    Mascalchi, Mario
    Bonuccelli, Ubaldo
    Inzitari, Domenico
    Pantoni, Leonardo
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2016, 368 : 195 - 202
  • [24] Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia
    Meyer, JS
    Rauch, G
    Rauch, RA
    Haque, A
    NEUROBIOLOGY OF AGING, 2000, 21 (02) : 161 - 169
  • [25] Cerebral Microbleeds Are Associated With Mild Cognitive Impairment in Patients With Hypertension
    Zhang, Jinbiao
    Liu, Lifeng
    Sun, Hairong
    Li, Menfan
    Li, Yan
    Zhao, Junwu
    Li, Jie
    Liu, Xinwu
    Cong, Yannan
    Li, Fang
    Li, Zhenguang
    JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2018, 7 (11):
  • [26] Cerebral vasomotor reactivity in patients with amnestic mild cognitive impairment
    Tomoto, T.
    Tarumi, T.
    Chen, J.
    Pasha, E. P.
    Zhang, R.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 : 334 - 335
  • [27] Cerebral metabolic heterogeneity in patients with mild cognitive impairment (MCI).
    Drzezga, A
    Minoshima, S
    Lautenschlager, N
    Reimenschneider, M
    Kurz, A
    Schwaiger, M
    JOURNAL OF NUCLEAR MEDICINE, 2000, 41 (05) : 64P - 64P
  • [28] Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment
    van Bergen, J. M. G.
    Li, X.
    Hua, J.
    Schreiner, S. J.
    Steininger, S. C.
    Quevenco, F. C.
    Wyss, M.
    Gietl, A. F.
    Treyer, V.
    Leh, S. E.
    Buck, F.
    Nitsch, R. M.
    Pruessmann, K. P.
    van Zijl, P. C. M.
    Hock, C.
    Unschuld, P. G.
    SCIENTIFIC REPORTS, 2016, 6
  • [29] Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment
    J. M. G. van Bergen
    X. Li
    J. Hua
    S. J. Schreiner
    S. C. Steininger
    F. C. Quevenco
    M. Wyss
    A. F. Gietl
    V. Treyer
    S. E. Leh
    F. Buck
    R. M. Nitsch
    K. P. Pruessmann
    P. C. M. van Zijl
    C. Hock
    P. G. Unschuld
    Scientific Reports, 6
  • [30] The influence of cerebral white matter hyperintensity on cognitive function in mild cognitive impairment
    Giubilei, F
    Sepe-Monti, M
    Bomboi, G
    Pantano, P
    De Carolis, A
    Bianchi, V
    Bozzao, L
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 238 : S287 - S287
12345