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Protective effect of antioxidants on brain oxidative damage caused by proline administration
被引:16
|作者:
Delwing, D
[1
]
Chiarani, F
[1
]
Bavaresco, CS
[1
]
Wannmacher, CMD
[1
]
Wajner, M
[1
]
Dutra, CS
[1
]
Wyse, ATS
[1
]
机构:
[1] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil
关键词:
disease metabolic;
hyperprolinemia;
oxidative stress;
glutathione;
antioxidants;
vitamins E and C;
D O I:
10.1016/j.neures.2005.01.011
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
We have previously demonstrated that acute and chronic hyperprolinemia induce oxidative stress in cerebral cortex of rats. In the present study, we investigated the action of Vitamins E and C on the oxidative damage elicited by acute and chronic administration of proline (Pro) in rat cerebral cortex. Results showed that treatment with Vitamins E and C prevented the alterations caused by acute and chronic administration of proline on chemiluminescence, total radical-trappin g antioxidant potential (TRAP) and on the activities of catalase and glutathione peroxidase. If these effects also occur in the human condition, it is possible that antioxidant administration might serve as a potential adjuvant therapy to avoid the progression of the neuropsychiatric dysfunction observed in hyperprolinemic patients. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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页码:69 / 74
页数:6
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