A Review of 3D Printing Technology for Medical Applications

被引:456
|
作者
Yan, Qian [1 ]
Dong, Hanhua [2 ]
Su, Jin [1 ]
Han, Jianhua [3 ]
Song, Bo [1 ]
Wei, Qingsong [1 ]
Shi, Yusheng [1 ]
机构
[1] Huazhong Univ Sci & Technol, State Key Lab Mat Proc & Die & Mould Technol, Wuhan 430074, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430074, Hubei, Peoples R China
[3] Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway
基金
国家重点研发计划;
关键词
3D printing; Implant; Scaffold; Biomedical material; MECHANICAL-PROPERTIES; TISSUE; SCAFFOLDS; CARTILAGE; ALLOY; BONE; DESIGN; TITANIUM; BEHAVIOR; NETWORK;
D O I
10.1016/j.eng.2018.07.021
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Donor shortages for organ transplantations are a major clinical challenge worldwide. Potential risks that are inevitably encountered with traditional methods include complications, secondary injuries, and limited source donors. Three-dimensional (3D) printing technology holds the potential to solve these limitations; it can be used to rapidly manufacture personalized tissue engineering scaffolds, repair tissue defects in situ with cells, and even directly print tissue and organs. Such printed implants and organs not only perfectly match the patient's damaged tissue, but can also have engineered material microstructures and cell arrangements to promote cell growth and differentiation. Thus, such implants allow the desired tissue repair to be achieved, and could eventually solve the donor-shortage problem. This review summarizes relevant studies and recent progress on four levels, introduces different types of biomedical materials, and discusses existing problems and development issues with 3D printing that are related to materials and to the construction of extracellular matrix in vitro for medical applications. (C) 2018 THE AUTHORS. Published by Elsevier LTD on behalf of Chinese Academy of Engineering and Higher Education Press Limited Company.
引用
收藏
页码:729 / 742
页数:14
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