Bioactive saponins from the fruits of Aesculus pavia L.

被引：1
|
作者：
Sun, Zhen-Liang [1 ]
Zhang, Ming [1 ]
Wu, Ying [1 ]
Wan, Ai-Hong [1 ]
Zhang, Rong [1 ]
机构：
[1] Shanghai 6 Peoples Hosp, Branch Hosp Fengxian, Shanghai 201400, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 07期
关键词：
Aesculus pavia L; Vaccaroside A; Cytotoxic activity; TRITERPENOID SAPONINS; STEROIDAL SAPONINS; FUROSTANOL SAPONINS; ROOTS;
D O I：
10.1016/j.fitote.2011.07.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Continued chemical investigation on the fruits of Aesculus pavia L resulted in the isolation and identification of two new oleanolic acid saponins. namely vaccaroside A (1) and vaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays. In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC50 valuesin the range of 27.80-79.02 mu M (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1106 / 1109
页数：4
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