Bioactive saponins from the fruits of Aesculus pavia L.

被引：1
|
作者：
Sun, Zhen-Liang [1 ]
Zhang, Ming [1 ]
Wu, Ying [1 ]
Wan, Ai-Hong [1 ]
Zhang, Rong [1 ]
机构：
[1] Shanghai 6 Peoples Hosp, Branch Hosp Fengxian, Shanghai 201400, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 07期
关键词：
Aesculus pavia L; Vaccaroside A; Cytotoxic activity; TRITERPENOID SAPONINS; STEROIDAL SAPONINS; FUROSTANOL SAPONINS; ROOTS;
D O I：
10.1016/j.fitote.2011.07.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Continued chemical investigation on the fruits of Aesculus pavia L resulted in the isolation and identification of two new oleanolic acid saponins. namely vaccaroside A (1) and vaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays. In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC50 valuesin the range of 27.80-79.02 mu M (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1106 / 1109
页数：4
相关论文
共 50 条
  • [1] Cytotoxic triterpenoid saponins from the fruits of Aesculus pavia L.
    Zhang, Zhizhen
    Li, Shiyou
    PHYTOCHEMISTRY, 2007, 68 (15) : 2075 - 2086
  • [2] Triterpenoid saponins from the fruits of Aesculus pavia
    Zhang, Zhizhen
    Li, Shiyou
    Zhang, Shanmin
    Gorenstein, David
    PHYTOCHEMISTRY, 2006, 67 (08) : 784 - 794
  • [3] Bioactive sapogenins and saponins from Allium porrum L.
    Fattorusso, E
    Lanzotti, V
    Taglialatela-Scafati, O
    FLAVOUR AND FRAGRANCE CHEMISTRY, 2000, 46 : 87 - 99
  • [4] STRUCTURE OF THE SAPOGENINS OF SEEDS FROM AESCULUS-PAVIA L
    SCHRUTKARECHTENSTAMM, R
    ROBIEN, W
    JURENITSCH, J
    PHARMAZIE, 1988, 43 (03): : 208 - 210
  • [5] Bioactive saponins from Astragalus suberi L. growing in Yemen
    Abbas, F
    Zayed, R
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2005, 60 (11-12): : 813 - 820
  • [6] Aesculus pavia foliar saponins: defensive role against the leafminer Cameraria ohridella
    Ferracini, Chiara
    Curir, Paolo
    Dolci, Marcello
    Lanzotti, Virginia
    Alma, Alberto
    PEST MANAGEMENT SCIENCE, 2010, 66 (07) : 767 - 772
  • [7] Bioactive Flavonoids from Cornus mas L. Fruits
    Moldovan, Bianca
    David, Luminita
    MINI-REVIEWS IN ORGANIC CHEMISTRY, 2017, 14 (06) : 489 - 495
  • [8] The bioactive constituents from the fruits of Elaeagnus angustifolia L.
    Fu, Yang
    Ruan, Jingya
    Zhang, Ping
    Zhang, Wei
    Yang, Dingshan
    Zhang, Yaqi
    Dang, Zhunan
    Zhang, Yi
    Wang, Tao
    PHYTOCHEMISTRY, 2025, 230
  • [9] Paviosides A-H, eight new oleane type saponins from Aesculus pavia with cytotoxic activity
    Lanzotti, Virginia
    Termolino, Pasquale
    Dolci, Marcello
    Curir, Paolo
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (10) : 3280 - 3286
  • [10] VARIATION AND TAXONOMY OF AESCULUS-PAVIA L (HIPPOCASTANACEAE) IN TEXAS
    WYATT, R
    LODWICK, LN
    BRITTONIA, 1981, 33 (01) : 39 - 51
12345