FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria

被引：62
|
作者：
Sun, Hongcheng [1 ]
Teng, Mujian [2 ]
Liu, Jie [2 ]
Jin, Dong [3 ]
Wu, Junyi [1 ]
Yan, Dongwang [1 ]
Fan, Junwei [1 ]
Qin, Xuebin [4 ]
Tang, Huamei [5 ]
Peng, Zhihai [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Affiliated Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
[2] Shangdong Univ, Affiliated Qianfoshan Hosp, Dept Hepatobiliary & Pancreat Surg, Jinan 250014, Shandong, Peoples R China
[3] Ningxia Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Yinchuan 750004, Ningxia Prov, Peoples R China
[4] Brigham & Womens Hosp, Dept Medicine, Boston, MA 02139 USA
[5] Shanghai Jiao Tong Univ, Sch Med, Affiliated Peoples Hosp 1, Dept Pathol, Shanghai 200080, Peoples R China
来源：
CANCER LETTERS | 2011年 / 306卷 / 02期
关键词：
Hepatocellular carcinoma; Orthotopic liver transplantation; FOXM1; Biomarker; TRANSCRIPTION FACTOR; EXPANSION; INVASION; IMPACT;
D O I：
10.1016/j.canlet.2011.03.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Molecular biomarker has been proposed to improve patient selection and post-transplant prognostication, but rare achievement has been made. In the present study, Forkhead box M1 (FOXM1) expression and its prognostic role have been investigated in hepatocellular carcinoma (HCC) treated by orthotopic liver transplantation (OLT). We found that the notably higher level of FOXM1 in tumors was associated with malignant pathological features of HCC and unfavorable outcome after OLT. The status of FOXM1 expression combined with the Milan criteria could make the prognostication more accurate and may be of particular interest for expanding the criteria in selecting transplant candidates. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：214 / 222
页数：9
相关论文
共 50 条
  • [21] Liver transplantation for hepatocellular carcinoma beyond the Milan criteria
    Xu, Xiao
    Lu, Di
    Ling, Qi
    Wei, Xuyong
    Wu, Jian
    Zhou, Lin
    Yan, Sheng
    Wu, Liming
    Geng, Lei
    Ke, Qinghong
    Gao, Feng
    Tu, Zhenhua
    Wang, Weilin
    Zhang, Min
    Shen, Yan
    Xie, Haiyang
    Jiang, Wenshi
    Wang, Haibo
    Zheng, Shusen
    GUT, 2016, 65 (06) : 1035 - 1041
  • [22] Liver Transplantation for Hepatocellular Carcinoma Beyond the Milan Criteria
    Gunsar, Fulya
    EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 2017, 15 : 59 - 64
  • [23] Simple Risk Score for Prediction of Early Recurrence of Hepatocellular Carcinoma within the Milan Criteria after Orthotopic Liver Transplantation
    Feng, Jiliang
    Wu, Jushan
    Zhu, Ruidong
    Feng, Dezhao
    Yu, Lu
    Zhang, Yan
    Bu, Dayu
    Li, Chenlei
    Zhou, Yuyan
    Si, Lianghao
    Liu, Yuhan
    Liang, Ziwei
    Xu, Jianing
    Wu, Tianjun
    SCIENTIFIC REPORTS, 2017, 7
  • [24] Simple Risk Score for Prediction of Early Recurrence of Hepatocellular Carcinoma within the Milan Criteria after Orthotopic Liver Transplantation
    Jiliang Feng
    Jushan Wu
    Ruidong Zhu
    Dezhao Feng
    Lu Yu
    Yan Zhang
    Dayu Bu
    Chenlei Li
    Yuyan Zhou
    Lianghao Si
    Yuhan Liu
    Ziwei Liang
    Jianing Xu
    Tianjun Wu
    Scientific Reports, 7
  • [25] Overexpression of Dickkopf-1 predicts poor prognosis for patients with hepatocellular carcinoma after orthotopic liver transplantation by promoting cancer metastasis and recurrence
    Yan Huang
    Xinrong Yang
    Fengbo Zhao
    Qiujin Shen
    Zhiwei Wang
    Xiufang Lv
    Baoying Hu
    Bin Yu
    Jia Fan
    Wenxin Qin
    Medical Oncology, 2014, 31
  • [26] Outcomes Of Liver Transplantation After Downstaging For Hepatocellular Carcinoma Beyond Milan Criteria
    Rao, Bhavana Bhagya
    Hammad, Abdulrahman
    Rome-Romarrero, Carlos J.
    Miller, Charles M.
    McLennan, Gordon
    Aucejo, Federico N.
    Menon, K. V. Narayanan
    HEPATOLOGY, 2017, 66 : 883A - 884A
  • [27] Overexpression of Dickkopf-1 predicts poor prognosis for patients with hepatocellular carcinoma after orthotopic liver transplantation by promoting cancer metastasis and recurrence
    Huang, Yan
    Yang, Xinrong
    Zhao, Fengbo
    Shen, Qiujin
    Wang, Zhiwei
    Lv, Xiufang
    Hu, Baoying
    Yu, Bin
    Fan, Jia
    Qin, Wenxin
    MEDICAL ONCOLOGY, 2014, 31 (07)
  • [28] Metastasis of hepatocellular carcinoma in the ovary after liver transplantation out of Milan criteria
    Coskun, Ebru Inci
    Kutluturk, Koray
    Yilmaz, Ercan
    Barut, Bora
    Isik, Burak
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2016, 26 : 41 - 41
  • [29] Recurrence of Hepatocellular Carcinoma According To Preoperative Milan Criteria After Liver Transplantation
    Valdivieso, Andres
    Bustamante, Javier
    Gastaca, Mikel
    Prieto, Mikel
    Ruiz, Patricia
    Pijoan, Ignacio
    Ventoso, Alberto
    Palomares, Ibone
    Ramon Fernandez, Jose
    Testillano, Milagros
    Ortiz-de-Urbina, Jorge
    TRANSPLANTATION, 2015, 99 : 226 - 226
  • [30] Tumor micronecrosis predicts poor prognosis of patients with hepatocellular carcinoma after liver transplantation
    Wang, Yangyang
    Zhang, Wei
    Ge, Hongbin
    Han, Xu
    Wu, Jiangchao
    Sun, Xuqi
    Sun, Ke
    Cao, Wanyue
    Huang, Chao
    Li, Jingsong
    Zhang, Qi
    Liang, Tingbo
    BMC CANCER, 2023, 23 (01)
12345