LncRNA H19 and Target Gene-mediated Cleft Palate Induced by TCDD

被引：7
|
作者：
Gao Li Yun [1 ]
Zhang Feng Quan [1 ]
Zhao Wei Hui [2 ]
Han Guang Liang [1 ]
Wang Xiao [1 ]
Li Qiang [1 ]
Gao Shan Shan [1 ]
Wu Wei Dong [1 ]
机构：
[1] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Henan, Peoples R China
[2] Xinxiang Med Univ, Dept Physiol & Neurobiol, Xinxiang 453003, Henan, Peoples R China
来源：
BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2017年 / 30卷 / 09期
基金：
中国国家自然科学基金;
关键词：
REGION;
D O I：
10.3967/bes2017.090
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
This study investigated the role of long non-coding RNAs (lncRNAs) in the development of the palatal tissues. Cleft palates in mice were induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Expression levels of long non-coding RNA H19 (lncRNA H19) and insulin-like growth factor 2 (IGF2) gene were measured by quantitative real-time polymerase chain reaction (qRT-PCR). The rate of occurrence of cleft palate was found to be 100% by TCDD exposure, and TCDD could cause short upper limb, cerebral fissure, webbed neck, and short neck. The expression levels of lncRNA H19 and IGF2 gene specifically showed embryo age-related differences on E13, E14, and E15 in the palatal tissues. The expression levels of lncRNA H19 and IGF2 gene showed an inverse relationship on E13, E14, and E15. These findings demonstrated that lncRNA H19 and IGF2 can mediate the development of mouse cleft palate.
引用
收藏
页码：676 / 680
页数：5
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