Microwave-Assisted One-pot Green Synthesis of 3-Methyl-4-((1-methyl-1H-indol-3-yl)methylene)isoxazol-5(4H)-ones

被引：0
|
作者：
Bireddy, Srinivasa Reddy [1 ]
Gaddam, Ganga Reddy [2 ]
Reddy, C. H. Venkata Ramana [2 ]
机构：
[1] Mahatma Gandhi Inst Technol, Dept Chem, Hyderabad, Telangana, India
[2] Jawaharlal Nehru Technol Univ Hyderabad, Dept Chem, Hyderabad, Telangana, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 04期
关键词：
Green conditions; Indole; Isaxozole; Knoevenagel condensation; L-Proline; Microwave irradiation; One-pot synthesis; FREE MULTICOMPONENT REACTIONS; SOLVENT-FREE; L-PROLINE; ANTIBACTERIAL ACTIVITY; ORGANIC-SYNTHESIS; EFFICIENT; CATALYST; DERIVATIVES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One-pot three component Knoevenagal condensation of 1-methyl-1H-indole-3-carbaldehyde with beta-ketoesters and hydroxylamine hydrochloride under microwave irradiation in the presence of L-Proline as a catalyst gave a series of 3-methyl-4-((1-methyl-1H-indol-3-yl)methylene)isoxazol-5(4H)-ones. The advantages of this protocol are green, efficient, less reaction time, easy workup, and high yields. Further, the catalyst can be recovered and reused.
引用
收藏
页码：603 / 612
页数：10
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