Microwave-Assisted One-pot Green Synthesis of 3-Methyl-4-((1-methyl-1H-indol-3-yl)methylene)isoxazol-5(4H)-ones

被引：0

作者：

Bireddy, Srinivasa Reddy ^{[1
]}

Gaddam, Ganga Reddy ^{[2
]}

Reddy, C. H. Venkata Ramana ^{[2
]}

机构：

[1] Mahatma Gandhi Inst Technol, Dept Chem, Hyderabad, Telangana, India

[2] Jawaharlal Nehru Technol Univ Hyderabad, Dept Chem, Hyderabad, Telangana, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 04期

关键词：

Green conditions; Indole; Isaxozole; Knoevenagel condensation; L-Proline; Microwave irradiation; One-pot synthesis; FREE MULTICOMPONENT REACTIONS; SOLVENT-FREE; L-PROLINE; ANTIBACTERIAL ACTIVITY; ORGANIC-SYNTHESIS; EFFICIENT; CATALYST; DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot three component Knoevenagal condensation of 1-methyl-1H-indole-3-carbaldehyde with beta-ketoesters and hydroxylamine hydrochloride under microwave irradiation in the presence of L-Proline as a catalyst gave a series of 3-methyl-4-((1-methyl-1H-indol-3-yl)methylene)isoxazol-5(4H)-ones. The advantages of this protocol are green, efficient, less reaction time, easy workup, and high yields. Further, the catalyst can be recovered and reused.

引用

页码：603 / 612

页数：10

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