Daratumumab Plus Ixazomib, Lenalidomide, and Dexamethasone As Extended Induction and Consolidation Followed By Lenalidomide Maintenance in Standard-Risk Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM) Patients (IFM 2018-01): A Phase II Study of the Intergroupe Francophone Du Myelome (IFM)

被引:10
|
作者
Perrot, Aurore [1 ]
Lauwers-Cances, Valerie [2 ]
Touzeau, Cyrille [3 ]
Decaux, Olivier [4 ]
Hulin, Cyrille [5 ]
Macro, Magaret [6 ]
Stoppa, Anne-Marie [7 ]
Chretien, Marie Lorraine [8 ]
Karlin, Lionel [9 ]
Mariette, Clara [10 ]
Jacquet, Caroline [11 ]
Roussel, Murielle [12 ]
Guillemot, Coralie [13 ]
Devlamynck, Laure [2 ]
Avet-Loiseau, Herve [14 ]
Moreau, Philippe [15 ]
Attal, Michel [16 ]
机构
[1] Ctr Hosp Univ Toulouse, Serv Hematol, Toulouse, France
[2] CHU Toulouse, serv Epidemiol, USMR, Toulouse, France
[3] CHU Nantes, Hematol, Ctr Rech Cancerol & Immunol Nantes Angers CRCINA, Nantes, France
[4] CHU Rennes, Serv Hematol, Rennes, France
[5] Hop Haut Leveque, Univ Hosp, Pessac, France
[6] Ctr Hosp Univ CHU Caen, Caen, France
[7] Inst Paoli Calmettes, Marseille, France
[8] CHU Dijon, Serv Hematol Clin, Dijon, France
[9] Univ Claude Bernard Lyon 1, CHU Lyon Sud, Hosp Civils Lyon, Dept Hematol, Pierre Benite, France
[10] CHU Grenoble, Serv Hematol, Grenoble, France
[11] CHRU Nancy, Vandoeuvre Les Nancy, France
[12] CHU Limoges, Hematol, Limoges, France
[13] IUCT Oncopole, Pharm Unite Essais Clin, Toulouse, France
[14] UPS, CHU Toulouse, Unite Genom Myelome, IUCT Oncopole, Toulouse, France
[15] CHU Nantes, Nantes, France
[16] Inst Univ Canc Toulouse Oncopole, Toulouse, France
关键词
D O I
10.1182/blood-2021-146040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
464
引用
收藏
页数:5
相关论文
共 50 条
  • [31] Daratumumab (DARA) Plus Lenalidomide, Bortezomib, and Dexamethasone (RVd) in Patients with Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM): Updated Efficacy and Safety Analysis of the Safety Run-in Population of Griffin
    Voorhees, Peter M.
    Rodriguez, Cesar
    Reeves, Brandi
    Nathwani, Nitya
    Costa, Luciano J.
    Lutska, Yana
    Bobba, Padma
    Hoehn, Daniela
    Pei, Huiling
    Ukropec, Jon
    Qi, Ming
    Lin, Thomas S.
    Richardson, Paul G.
    BLOOD, 2020, 136
  • [32] Depth of Response to Daratumumab (DARA), Lenalidomide, Bortezomib, and Dexamethasone (RVd) Improves over Time in Patients (pts) with Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM): Griffin Study Update
    Voorhees, Peter M.
    Kaufman, Jonathan L.
    Laubach, Jacob P.
    Sborov, Douglas W.
    Reeves, Brandi
    Rodriguez, Cesar
    Chari, Ajai
    Silbermann, Rebecca W.
    Costa, Luciano J.
    Anderson, Larry D.
    Nathwani, Nitya
    Shah, Nina D.
    Efebera, Yvonne A.
    Costello, Caitlin L.
    Jakubowiak, Andrzej
    Wildes, Tanya M.
    Orlowski, Robert Z.
    Shain, Kenneth H.
    Cowan, Andrew J.
    Murphy, Sean
    Lutska, Yana
    Pei, Huiling
    Ukropec, Jon
    Vermeulen, Jessica
    de Boer, Carla
    Hoehn, Daniela
    Lin, Thomas S.
    Richardson, Paul G.
    BLOOD, 2019, 134
  • [33] Updated Analysis of Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma (NDMM): The Phase 3 Maia Study
    Kumar, Shaji K.
    Facon, Thierry
    Usmani, Saad Z.
    Plesner, Torben
    Orlowski, Robert Z.
    Touzeau, Cyrille
    Basu, Supratik
    Bahlis, Nizar J.
    Goldschmidt, Hartmut
    O'Dwyer, Michael E.
    Venner, Christopher P.
    Weisel, Katja
    Hulin, Cyrille
    Karlin, Lionel
    Preis, Meir
    Broyl, Annemiek
    Renwick, William
    Hansson, Markus
    Krevvata, Maria
    Wang, Jianping
    Van Rampelbergh, Rian
    Ukropec, Jon
    Uhlar, Clarissa M.
    Kobos, Rachel
    Perrot, Aurore
    BLOOD, 2020, 136
  • [34] Bortezomib, lenalidomide, and dexamethasone (VRd) daratumumab (DARA) in patients (pts) with transplant -eligible (TE) newly diagnosed multiple myeloma (NDMM): A multicenter, randomized, phase Ill study (PERSEUS).
    Sonneveld, Pieter
    Broijl, Annemiek
    Gay, Francesca
    Boccadoro, Mario
    Einsele, Hermann
    Blade, Joan
    Dimopoulos, Meletios A.
    Delforge, Michel
    Spencer, Andrew
    Hajek, Roman
    Schjesvold, Fredrik
    Lonergan, Sarah
    Smith, Elena
    Carson, Robin L.
    Crist, Wendy
    Garvin, Wendy S.
    Vermeulen, Jessica
    Moreau, Philippe
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [35] Daratumumab (DARA) plus bortezomib/lenalidomide/dexamethasone (VRd) in transplant-eligible (TE) patients (pts) with newly diagnosed multiple myeloma (NDMM): Analysis of minimal residual disease (MRD) in the PERSEUS trial.
    Rodriguez-Otero, Paula
    Moreau, Philippe
    Dimopoulos, Meletios Athanasios
    Beksac, Meral
    Perrot, Aurore
    Broijl, Annemiek
    Gay, Francesca
    Mina, Roberto
    van de Donk, Niels W. C. J.
    Schjesvold, Fredrik
    Delforge, Michel
    Einsele, Hermann
    Spencer, Andrew
    Lonergan, Sarah
    Vieyra, Diego
    Sitthi-Amorn, Anna
    Carson, Robin L.
    Blade, Joan
    Boccadoro, Mario
    Sonneveld, Pieter
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [36] Daratumumab plus Bortezomib/ Lenalidomide/Dexamethasone (D-VRd) in Transplant-Eligible (TE) Patients With Newly Diagnosed Myeloma (NDMM): Analysis of the Phase 3 PERSEUS Study Based on High-Risk Cytogenetic Abnormalities (HRCAs)
    Dimopoulos, Meletios A.
    Sonneveld, Pieter
    Rodriguez-Otero, Paula
    Quach, Hang
    Ho, P. Joy
    Beksac, Meral
    Hulin, Cyrille
    Antonioli, Elisabetta
    Leleu, Xavier
    Mangiacavalli, Silvia
    Perrot, Aurore
    Cavo, Michele
    Belotti, Angelo
    Broijl, Annemiek
    Gay, Francesca
    Mina, Roberto
    Nijhof, Inger S.
    van de Donk, Niels W. C. J.
    Katodritou, Eirini
    Schjesvold, Fredrik
    Balari, Anna Sureda
    Rosinol, Laura
    Delforge, Michel
    Roeloffzen, Wilfried
    Driessen, Christoph
    Vangsted, Annette
    Einsele, Hermann
    Spencer, Andrew
    Hajek, Roman
    Jurczyszyn, Artur
    Lonergan, Sarah
    Liu, Yanfang
    Wang, Jianping
    Vieyra, Diego
    van Brummelen, Emilie M. J.
    Vanquickelberghe, Veronique
    Sitthi-Amorn, Anna
    de Boer, Carla J.
    Carson, Robin
    Blade, Joan
    Boccadoro, Mario
    Moreau, Philippe
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 : S547 - S548
  • [37] Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) Alone in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma (NDMM): Updated Analysis of the Phase 3 MAIA Study
    Kumar, S. K.
    Moreau, P.
    Bahlis, N.
    Facon, T.
    Plesner, T.
    Orlowski, R. Z.
    Basu, S.
    Nahi, H.
    Hulin, C.
    Quach, H.
    Goldschmidt, H.
    O'Dwyer, M.
    Perrot, A.
    Venner, C. P.
    Weisel, K.
    Raje, N.
    Tiab, M.
    Macro, M.
    Frenzel, L.
    Leleu, X.
    Wang, G.
    Krevvata, M.
    Carson, R.
    Borgsten, F.
    Usmani, S. Z.
    ONCOLOGY RESEARCH AND TREATMENT, 2023, 46 : 183 - 184
  • [38] Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) Alone in Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma (NDMM): Updated Analysis of the Phase 3 Maia Study
    Kumar, Shaji K.
    Moreau, Philippe
    Bahlis, Nizar Jacques
    Facon, Thierry
    Plesner, Torben
    Orlowski, Robert Z.
    Basu, Supratik
    Nahi, Hareth
    Hulin, Cyrille
    Quach, Hang
    Goldschmidt, Hartmut
    O'Dwyer, Michael
    Perrot, Aurore
    Venner, Christopher P.
    Weisel, Katja
    Raje, Noopur
    Tiab, Mourad
    Macro, Margaret
    Frenzel, Laurent
    Leleu, Xavier
    Pei, Huiling
    Krevvata, Maria
    Carson, Robin
    Borgsten, Fredrik
    Usmani, Saad
    BLOOD, 2022, 140 : 10150 - 10153
  • [39] A prospective phase 2 study to assess minimal residual disease after ixazomib plus lenalidomide plus dexamethasone (IRd) treatment for newly diagnosed transplant eligible multiple myeloma patients
    Silvennoinen, Raija
    Waage, Anders
    Peceliunas, Valdas
    Schjesvold, Fredrik
    Anttila, Pekka
    Uttervall, Katarina
    Saily, Marjaana
    Putkonen, Mervi
    Carlson, Kristina
    Haukas, Einar
    Sankelo, Marja
    Partanen, Anu
    Szatkowski, Damian
    Hansson, Markus
    Marttila, Anu
    Svensson, Ronald
    Axelsson, Per
    Lauri, Birgitta
    Mikkola, Maija
    Karlsson, Conny
    Abelsson, Johanna
    Ahlstrand, Erik
    Sikio, Anu
    Nahi, Hareth
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 : S157 - S157
  • [40] High-Risk Multiple Myeloma in Benefit (IFM 2020-05) Phase 3 Randomized Study of Isatuximab (Isa) Plus Lenalidomide and Dexamethasone (Rd) with Bortezomib Versus Isard in Patients with Newly Diagnosed Transplant Ineligible Multiple Myeloma (NDMM TI)
    Corre, Jill
    Lambert, Jerome
    Bobin, Arthur
    Manier, Salomon
    Perrot, Aurore
    Karlin, Lionel
    Roussel, Murielle
    Bigot, Noemie
    Benbrahim, Omar
    Allangba, Olivier Thierry
    Rey, Philippe
    Dorvaux, Veronique
    Vignon, Marguerite
    Roland, Virginie
    Garidi, Reda
    Bastie, Jean-Noel
    Chretien, Marie-Lorraine
    Godet, Sophie
    Montes, Lydia
    Cherel, Brieuc
    Chalopin, Thomas
    Slama, Borhane
    Laribi, Kamel
    Dingremont, Claire
    Roul, Christophe
    Richez, Valentine
    Mariette, Clara
    Rigaudeau, Sophie
    Calmettes, Claire
    Dib, Mamoun
    Tiab, Mourad
    Vincent, Laure
    Delaunay, Jacques
    Marolleau, Jean Pierre
    Godmer, Pascal
    Frenzel, Laurent
    Le Calloch, Ronan
    Chalayer, Emilie
    Gardeney, Helene
    Macro, Margaret
    Royer, Bruno
    Decaux, Olivier
    Arnulf, Bertrand
    Merzoug, Karim Belhadj
    Touzeau, Cyrille
    Mohty, Mohamad
    Gontier, Aurelie
    Kasmi, Amine
    Moreau, Philippe
    Facon, Thierry
    BLOOD, 2024, 144 : 4756 - 4758