Ruthenium-Catalyzed Cycloisomerization and Its Application to the Synthesis of (±)-Cinchonaminone

被引：10

作者：

Ogawa, Takao ^{[1
]}

Nakamura, Tomonori ^{[2
]}

Araki, Takuya ^{[2
]}

Yamamoto, Koujirou ^{[2
]}

Shuto, Satoshi ^{[1
]}

Arisawa, Mitsuhiro ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

[2] Gunma Univ, Dept Clin Pharmacol, Grad Sch Med, Maebashi, Gunma 3718511, Japan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 16期

关键词：

Heterocycles; Cyclization; Ruthenium; Natural products; Total synthesis; INDOLES; CARBOCYCLIZATIONS; CARBENE; ISOMERIZATION; REARRANGEMENT;

D O I：

10.1002/ejoc.201200260

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ru-catalyzed cycloisomerization of a 1,3-diene and the alkene of an N-dienyl-2-vinylaniline substrate proceeded smoothly, leading to a 3-exomethylene-2-vinylindole derivative in good yield. This useful synthon was successfully applied to the total synthesis of (+/-)-cinchonaminone.

引用

页码：3084 / 3087

页数：4

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