Stem Cells in Bone Regeneration

被引：117

作者：

Walmsley, Graham G. ^{[1
,2
]}

Ransom, Ryan C. ^{[1
,2
]}

Zielins, Elizabeth R. ^{[1
]}

Leavitt, Tripp ^{[1
]}

Flacco, John S. ^{[1
]}

Hu, Michael S. ^{[2
,3
]}

Lee, Andrew S. ^{[2
]}

Longaker, Michael T. ^{[1
,2
]}

Wan, Derrick C. ^{[1
]}

机构：

[1] Stanford Univ, Div Plast & Reconstruct Surg, Dept Surg, Hagey Lab Pediat Regenerat Med,Sch Med, 257 Campus Dr Room GK106, Stanford, CA 94305 USA

[2] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Hagey Bldg,257 Campus Dr, Stanford, CA 94305 USA

[3] Univ Hawaii, John A Burns Sch Med, Dept Surg, Honolulu, HI 96822 USA

来源：

STEM CELL REVIEWS AND REPORTS | 2016年 / 12卷 / 05期

关键词：

Stem cell; Bone; Regeneration; Tissue; Engineering; MECHANICAL-PROPERTIES; MOLECULAR ASPECTS; MARROW ASPIRATE; IDENTIFICATION; NICHE; SIZE;

D O I：

10.1007/s12015-016-9665-5

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Bone has the capacity to regenerate and repair itself. However, this capacity may be impaired or lost depending on the size of the defect or the presence of certain disease states. In this review, we discuss the key principles underlying bone healing, efforts to characterize bone stem and progenitor cell populations, and the current status of translational and clinical studies in cell-based bone tissue engineering. Though barriers to clinical implementation still exist, the application of stem and progenitor cell populations to bone engineering strategies has the potential to profoundly impact regenerative medicine.

引用

页码：524 / 529

页数：6

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