Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex

被引：5
|
作者：
Shiotani, Motohiro [1 ]
Nakano, Kyoko [1 ]
Yamauchi, Emiko [2 ]
Oda, Yoshiya [2 ]
Hosokawa, Satoru [1 ]
Aoki, Toyohiko [1 ]
机构：
[1] Eisai Prod Creat Syst, Drug Safety Japan, Global Drug Safety, Biopharmaceut Assessments Core Funct Unit, Tsukuba, Ibaraki 3002635, Japan
[2] Eisai Prod Creat Syst, Biomarkers & Personalized Med Core Funct Unit, Andover, MA 01810 USA
来源：
JOURNAL OF TOXICOLOGICAL SCIENCES | 2011年 / 36卷 / 01期
关键词：
MK-801; NMDA; Vacuolation; Rat; Proteomics; PHENCYCLIDINE; NEUROTOXICITY; DIZOCILPINE; RECEPTORS; NECROSIS; PROTEIN; DRUGS;
D O I：
10.2131/jts.36.131
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (se) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).
引用
收藏
页码：131 / 133
页数：3
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