Tumor Suppression by p53: Bring in the Hippo!

被引：9
|
作者：
Aylon, Yael [1 ]
Oren, Moshe [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel
来源：
CANCER CELL | 2017年 / 32卷 / 04期
关键词：
PROTEINS; PATHWAY; RAS;
D O I：
10.1016/j.ccell.2017.09.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Mello et al. investigated how p53 suppresses pancreatic cancer and discovered a key role for the tyrosine phosphatase PTPN14, a p53 transcriptional target. PTPN14 restrains YAP, curbing its potential oncogenic effects. The p53-PTPN14-YAP axis highlights the importance of signaling pathway coordination in cancer prevention.
引用
收藏
页码：397 / 399
页数：4
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