Wnt/Axin1/β-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries

被引:79
|
作者
Carl, Matthias
Bianco, Isaac H.
Bajoghli, Baubak
Aghaallaei, Narges
Czerny, Thomas
Wilson, Stephen W.
机构
[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England
[2] Univ Vet Med, Inst Genet & Anim Breeding, A-1210 Vienna, Austria
[3] Univ Appl Sci, Vienna Bioctr, A-1030 Vienna, Austria
基金
英国生物技术与生命科学研究理事会; 英国惠康基金; 英国医学研究理事会;
关键词
D O I
10.1016/j.neuron.2007.07.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Nodal activity in the left lateral plate mesoderm (LPM) is required to activate left-sided Nodal signaling in the epithalamic region of the zebrafish forebrain. Epithalamic Nodal signaling subsequently determines the laterality of neuroanatomical asymmetries. We show that overactivation of Wnt/Axin1/beta-catenin signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of LPM Nodal signaling. This is consistent with a model whereby epithalamic Nodal signaling is normally bilaterally repressed, with Nodal signaling from the LPM unilaterally alleviating repression. We suggest that Wnt signaling regulates the establishment of the bilateral repression. We identify a second role for the Wnt pathway in the left/right regulation of LPM Nodal pathway gene expression, and finally, we show that at later stages Axin1 is required for the elaboration of concordant neuroanatomical asymmetries.
引用
收藏
页码:393 / 405
页数:13
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